Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7851 - 7900 OF 15971 RESULTS

January 1, 2013

Pharmacokinetic drivers of toxicity for basic molecules: Strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor

Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333

Dolores Diaz; Kevin A. Ford; Dylan P. Hartley; Eric Harstad; Cain; Kirsten Achilles Poon; Trung Nguyen; Jing Peng; Zhong Zheng; Mark Merchant; Daniel P. Sutherlin; John J. Gaudino; Robert Kaus; Sock-Cheng Lewin-Koh; Edna F. Choo; Bianca M. Liederer; Donna M. Dambach

January 1, 2013

Characterization of monoclonal antibody size variants containing extra light chains

mAbs, ISSN: 19420862 19420870

Connie Lu; Dandan Liu; Hongbin Liu; Paul Motchnik

January 1, 2013

Cost-effectiveness of hub-and-spoke telestroke networks for the management of acute ischemic stroke from the hospitals' perspectives

Circulation: Cardiovascular Quality and Outcomes, ISSN: 19417713 19417705

Jeffrey A. Switzer; Bart M. Demaerschalk; Jipan Xie; Liangyi Fan; Kathleen F. Villa; Eric Q. Wu

January 1, 2013

Drug-to-antibody ratio (DAR) and drug load distribution by hydrophobic interaction chromatography and reversed phase high-performance liquid chromatography

Methods in Molecular Biology, ISSN: 10643745

Jun Ouyang

January 1, 2013

PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Edna F. Choo; Chee Ng; Berry; Marcia Belvin; Nicholas Lewin-Koh; Mark Merchant; Laurent Salphati

January 1, 2013

American Association of Pharmaceutical Scientists National Biotechnology Conference short course: Translational challenges in developing antibody-drug conjugates

mAbs, ISSN: 19420862 19420870

Karen Thudium; Sanela Bilic; Douglas Leipold; William Mallet; Surinder Kaur; Bernd Meibohm; Hans Erickson; Jay Tibbitts; Hong Zhao; Manish Gupta

January 1, 2013

Stratification of randomization is not required for a pre-specified subgroup analysis

Pharmaceutical Statistics, ISSN: 15391604 15391612

Lee D. Kaiser

January 1, 2013

Adverse events associated with bevacizumab and chemotherapy in older patients with metastatic colorectal cancer

Clinical Colorectal Cancer, ISSN: 19380674 15330028

Veena Shankaran; David Mummy; Lisel Koepl; David Blough; Yeun Mi Yim; Elaine B. Yu; Scott D. Ramsey

January 1, 2013

Recombinant human deoxyribonuclease I

Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition,

Lazarus; Wagener

January 1, 2013

An educational intervention to improve resident comfort with communication at the end of life

Journal of Palliative Medicine, ISSN: 10966218 15577740

Leah Smith; Patricia O'Sullivan; Bernard Lo; Hubert Chen

January 1, 2013

A preclinical mouse model of invasive lobular breast cancer metastasis

Cancer Research, ISSN: 00085472 15387445

Chris W. Doornebal; Sjoerd Klarenbeek; Tanya M. Braumuller; Christiaan N. Klijn; Metamia Ciampricotti; Cheei-Sing Hau; Markus W. Hollmann; Jos Jonkers; Karin E. De Visser

January 1, 2013

Antibody-Drug Conjugates for the Treatment of Cancer

Chemical Biology and Drug Design, ISSN: 17470277 17470285

Flygare; Thomas H. Pillow; Paul Aristoff

January 1, 2013

Drug-to-antibody ratio (DAR) and drug load distribution by LC-ESI-MS

Methods in Molecular Biology, ISSN: 10643745

Basa

January 1, 2013

Bioanalytical assay strategies for the development of antibody-drug conjugate biotherapeutics

Bioanalysis, ISSN: 17576180 17576199

Surinder Kaur; Keyang Xu; Ola M. Saad; Randall Dere; Montserrat Carrasco-Triguero

January 1, 2013

Hplc systems and modules introduced at pittcon 2013: A brief review

LCGC North America, ISSN: 15275949

Michael W. Dong

January 1, 2013

A tumor-specific stem cell

Nature Genetics, ISSN: 10614036 15461718

Ciara Metcalfe; Frederic J. De Sauvage

January 1, 2013

Recent challenges and opportunities for biotechnology: A perspective from commercial manufacturing

Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future,

Luo; Mills; Jesse Bergevin

January 1, 2013

Myths in ultrahigh-pressure liquid chromatography

LCGC North America, ISSN: 15275949

Michael W. Dong

January 1, 2013

Concomitant asthma medications in moderate-to-severe allergic asthma treated with omalizumab

Respiratory Medicine, ISSN: 09546111 15323064

Hubert Chen; Mark D. Eisner; Tmirah Haselkorn; Benjamin L. Trzaskoma

January 1, 2013

A model of cost-effectiveness of tissue plasminogen activator in patient subgroups 3 to 4.5 hours after onset of acute ischemic stroke

Annals of Emergency Medicine, ISSN: 01960644 10976760

Denise M. Boudreau; Gregory F. Guzauskas; Kathleen F. Villa; Susan C. Fagan; David L. Veenstra

January 1, 2013

Drug-to-antibody ratio (DAR) by UV/Vis spectroscopy

Methods in Molecular Biology, ISSN: 10643745

Yan Chen

January 1, 2013

Co-administration of vismodegib with rosiglitazone or combined oral contraceptive in patients with locally advanced or metastatic solid tumors: A pharmacokinetic assessment of drug-drug interaction potential

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Patricia M. LoRusso; Sarina A. Piha-Paul; Monica Mita; A. Dimitrios Colevas; Vikram Malhi; Dawn Colburn; Ming Yin; Low; Richard A. Graham

January 1, 2013

Effects of trastuzumab emtansine (T-DM1) on Qt interval and safety of pertuzumab plus T-DM1 in patients with previously treated human epidermal growth factor receptor 2-positive metastatic breast cancer

Clinical Pharmacology in Drug Development, ISSN: 2160763X 21607648

Manish Gupta; Wang; Timothy J. Carrothers; Patricia M. LoRusso; Yu-Waye Chu; Ted Shih; David Loecke; Amita Joshi; Ola M. Saad; Joo-Hee Yi; Sandhya Girish

January 1, 2013

Driving ability reported by neovascular age-related macular degeneration patients after treatment with ranibizumab

Ophthalmology, ISSN: 01616420 15494713

Neil M. Bressler; Tom S. Chang; Rohit Varma; Ivan J. Suñer; Paul P. Lee; Chantal M. Dolan; James Ward; Tsontcho Ianchulev; Jennifer T. Fine

January 1, 2013

A phase i study of tasisulam sodium (LY573636 sodium), a novel anticancer compound, administered as a 24-h continuous infusion in patients with advanced solid tumors

Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843

Michael S. Gordon; Robert L. Ilaria Jr.; Dinesh P. De Alwis; David Mendelson; Scott McKane; Margaret M. Wagner; Katherine Y. Look; Patricia M. LoRusso

January 1, 2013

Application of second-derivative fluorescence spectroscopy to monitor subtle changes in a monoclonal antibody structure

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Shermeen A. Abbas; Greta Gaspar; Vikas Sharma; Thomas W. Patapoff; Devendra S. Kalonia

January 1, 2013

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology

Toxicological Sciences, ISSN: 10966080 10960929

Rebecca Erickson; Jacqueline M. Tarrant; Cain; Sock-Cheng Lewin-Koh; Noel Dybdal; Harvey Wong; Elizabeth M. Blackwood; Kristina West; Ronald Steigerwalt; Michael Mamounas; Flygare; Kenjie Amemiya; Donna M. Dambach; Wayne J. Fairbrother; Dolores Diaz

January 1, 2013

Anatomical measures as predictors of visual outcomes in ranibizumab-treated eyes with neovascular age-related macular degeneration

Retina, ISSN: 0275004X 15392864

David M. Brown; Lisa Tuomi; Howard Shapiro

January 1, 2013

Network quantification of EGFR signaling unveils potential for targeted combination therapy

Molecular Systems Biology, ISSN: 17444292

Bertram Klinger; Anja Sieber; Raphaela Fritsche-Guenther; Franziska Witzel; Berry; Dirk Schumacher; Yibing Yan; Pawel Durek; Mark Merchant; Reinhold Schäfer; Christine Sers; Nils Blüthgen

January 1, 2013

ImmunoPET imaging of phosphatidylserine in pro-apoptotic therapy treated tumor models

Nuclear Medicine and Biology, ISSN: 09698051 18729614

Annie Ogasawara; Jeff N. Tinianow; Alexander N. Vanderbilt; Herman S. Gill; Sharon Fong Yee; Judith E. Flores; Simon P. Williams; Avi Ashkenazi; Jan Marik

January 1, 2013

An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: Case study of TENB2

British Journal of Pharmacology, ISSN: 00071188 14765381

C. Andrew Boswell; Eduardo E. Mundo; Ron Firestein; Crystal Zhang; Mao; Herman S. Gill; Cynthia Young; Nina Ljumanovic; Shannon Stainton; Sheila Ulufatu; Aimee Fourie-O'Donohue; Katherine R. Kozak; Reina N. Fuji; Paul G. Polakis; Leslie A. Khawli; Kedan Lin

January 1, 2013

Health-related quality of life with adjuvant docetaxel- and trastuzumab-based regimens in patients with node-positive and high-risk node-negative, her2-positive early breast cancer: Results from the BCIRG 006 study

Oncologist, ISSN: 1549490X 10837159

Heather-Jane Au; Wolfgang Eiermann; Nicholas J. Robert; Tadeusz Pienkowski; John Crown; Miguel Martín; Marek Pawlicki; Chan; John Mackey; John A. Glaspy; Tamás Pintér; Mei-Ching Liu; Tommy Fornander; Sandeep Sehdev; Jean-Marc Ferrero; Valerie Bée; Maria J. Santana; Dave P. Miller; Deepa Lalla; Dennis J. Slamon

January 1, 2013

Identification of preferred chemotherapeutics for combining with a CHK1 Inhibitor

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Yang Xiao; Judi Ramiscal; Kaska Kowanetz; Christopher J. Del Nagro; Shiva Malek; Marie Evangelista; Elizabeth M. Blackwood; Peter K Jackson; Thomas O'Brien

January 1, 2013

Current Practices in Preclinical Drug Development: Gaps in Hemostasis Testing to Assess Risk of Thromboembolic Injury

Toxicologic Pathology, ISSN: 15331601 01926233

A. Eric Schultze; Dana Walker; James R. Turk; Jacqueline M. Tarrant; Marjory B. Brooks; Syril D. Pettit

January 1, 2013

Altering the apoptotic network in cancer: A promising therapeutic approach

4th International Conference on Biomolecular Engineering, ICBE 2013,

Deshayes

January 1, 2013

IL-22 from conventional NK cells is epithelial regenerative and inflammation protective during influenza infection

Mucosal Immunology, ISSN: 19330219 19353456

Pawan Kumar; Monica S. Thakar; Wenjun Ouyang; Subramaniam Malarkannan

January 1, 2013

Lupus nephritis: Induction therapy in severe lupus nephritis-should MMF be considered the drug of choice?

Clinical Journal of the American Society of Nephrology, ISSN: 1555905X 15559041

Brad H. Rovin; Samir V. Parikh; Lee A. Hebert; Tak Mao Chan; Chi Chiu Mok; Ginzler; Lai Seong Hooi; Paul Brunetta; Romeo MacIuca; Neil Solomons

January 1, 2013

Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice

Journal of Clinical Investigation, ISSN: 15588238 00219738

Tiffany Chang; Kimberly Krisman; Emily Harding Theobald; Jin Xu; Jon Akutagawa; Jennifer O. Lauchle; Scott Kogan; Benjamin S. Braun; Kevin Shannon

January 1, 2013

UHPLC for Characterization of Protein Therapeutics

Ultra High Performance Liquid Chromatography and Its Applications,

Jennifer C. Rea; Yajun Jennifer Wang; Taylor Zhang

January 1, 2013

Biopharmaceuticals

Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3,

Wendy Halpern; David Hutto

January 1, 2013

Regarding confirmatory immunogenicity assays

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085

Daniel A. Coleman; Robert Hendricks; Reginald Delarosa; Eric Wakshull

January 1, 2013

Dependence of tumor cell lines and patient-derived tumors on the NAD salvage pathway renders them sensitive to NAMPT inhibition with GNE-6181

Neoplasia (United States), ISSN: 14765586 15228002

Yang Xiao; Kristi Elkins; Jenni K. Durieux; Leslie Lee; Jason Oeh; Lulu Yang; Xiaorong Liang; Christopher J. Del Nagro; Jarrod Tremayne; Mandy Kwong; Bianca M. Liederer; Peter K Jackson; Lisa D. Belmont; Deepak Sampath; Thomas O'Brien

January 1, 2013

The ASXL-BAP1 axis: New factors in myelopoiesis, cancer and epigenetics

Leukemia, ISSN: 08876924 14765551

Omar Abdel-Wahab; Anwesha Dey

January 1, 2013

Validation and application of a liquid chromatography-tandem mass spectrometric method for the determination of GDC-0152 in human plasma using solid-phase extraction

Biomedical chromatography : BMC, ISSN: 02693879 10990801

Young G. Shin; Steve A. Jones; Stanley Murakami; Nageshwar Budha; Joseph A. Ware; Harvey Wong; Michael H. Buonarati; Brian J. Dean; Cornelis E. Hop

January 1, 2013

Software for Computing and Annotating Genomic Ranges

PLoS Computational Biology, ISSN: 15537358 1553734X

Michael Lawrence; Wolfgang Huber; Hervé Pagès; Patrick Aboyoun; Marc Carlson; Robert Gentleman; Martin Morgan; Vincent J. Carey

January 1, 2013

SH3 interactome conserves general function over specific form

Molecular Systems Biology, ISSN: 17444292

Xiaofeng Xin; David Gfeller; Jackie Cheng; Raffi Tonikian; Lin Sun; Ailan Guo; Lianet Lopez; Alevtina Pavlenco; Adenrele Akintobi; Yingnan Zhang; Jean-François Rual; Bridget Currell; Somasekar Seshagiri; Tong Hao; Xinping Yang; Yun A. Shen; Kourosh Salehi-Ashtiani; Jingjing Li; Aaron T. Cheng; Dryden Bouamalay; Adrien Lugari; David E. Hill; Mark L. Grimes; Drubin; Barth D. Grant; Marc Vidal; Charles Boone; Sachdev S. Sidhu; Gary D. Bader

January 1, 2013

Noncanonical inflammasome activation by intracellular LPS independent of TLR4

Science, ISSN: 10959203 00368075

Nobuhiko Kayagaki; Michael T. Wong; Irma B. Stowe; Sree R. Ramani; Lino C. Gonzalez Jr.; Sachiko Akashi; Kensuke Miyake; Juan Zhang; Wyne P. Lee; Artur Muszynśki; Lennart S. Forsberg; Russell W. Carlson; Vishva M. Dixit

January 1, 2013

Emerging biomarkers in inflammatory bowel disease (embark) study identifies fecal calprotectin, serum mmp9, and serum il-22 as a novel combination of biomarkers for crohn's disease activity: Role of cross-sectional imaging

American Journal of Gastroenterology, ISSN: 15720241 00029270

William A. Faubion Jr.; Joel G Fletcher; Sharon O'Byrne; Brian G. Feagan; Willem J.S. de Villiers; Bruce Salzberg; Scott E. Plevy; Deborah D Proctor; John F Valentine; Higgins; Harris; Laurie Diehl; Lilyan Y. Wright; Tew; Diana Luca; Karen Basu; Mary E. Keir

January 1, 2013

Isomerization of Asp-Asp motif in model peptides and a monoclonal antibody fab fragment

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Li Yi; Nia S. Beckley; Benson Gikanga; Jennifer Zhang; Y. John Wang; Hung-Wei Chih; Vikas Sharma

January 1, 2013

Correlation of tissue-plasma partition coefficients between normal tissues and subcutaneous xenografts of human tumor cell lines in mouse as a prediction tool of drug penetration in tumors

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Patrick Poulin; Cornelis E. Hop; Laurent Salphati; Bianca M. Liederer

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