Understanding Multiple Sclerosis
MS is a disease of the central nervous system (CNS), which includes the brain, spinal cord and optic nerves. It is one disease, but its course and symptoms vary from person to person.
Who Gets MS?
MS is a leading cause of non-traumatic disability for young people.1,2
MS prevalence is highest in countries furthest from the equator4
Approximately 1 in 710 people
in North America have MS2
Approximately 1 in 925 people
in Europe have MS2
Approximately 1 in 1050 people
in Australia have MS2
Symptoms Can Affect Nearly Every Part of the Body and the Mind
People with MS can experience many types of symptoms.5
Experienced by up to 90% of people with MS6
Experienced by more than 50% of people with MS within 15 years of onset5,7,8
Common, and a first symptom in 15-20% of people with MS9
Experienced by at least 80% of people with MS10
Approximately 2x more likely in people with MS11
Twice as likely in people with MS12
MS has Different Disease Courses
MS is categorized into courses based on how the disease generally behaves and whether or not there is disease activity and a steady increase in disability over time. For explanation of disease courses, please visit the National Multiple Sclerosis Society. 13
SECONDARY PROGRESSIVE MS
PRIMARY PROGRESSIVE MS
Disease Activity can be Measured
No matter what course of MS a person has, relapsing or progressive forms of MS may be active or inactive at different points in time.14 Disease activity may be outwardly apparent with new or worsening signs or symptoms (relapses or disability progression). There can also be underlying disease activity that is detected with special equipment like magnetic resonance imaging (MRI).
A relapse, or exacerbation of MS (also known as an attack or flare-up), causes new symptoms or the worsening of old symptoms.15 The attack must last at least 24 hours and be separated from the previous attack by at least one month. Most relapses last from a few days to several weeks or even months, and can be followed by an incomplete or full recovery.
How fast or slow disability worsens may vary, but progression is a sustained increase in disability over time.
Lesions are inflamed or damaged areas of the CNS that can be seen with MRI. Lesions may appear or grow larger without immediately noticeable consequences, but can be a sign of irreversible damage that may lead to disability progression.16
More is Being Done
There is no cure for MS, but research continues to better understand and treat the disease.5
What causes MS?
What new ways can disease activity be monitored?
How can we better study new medicines for MS?
How can we predict which patients will benefit from a certain treatment?
1 Murray TJ. (2006). Diagnosis and treatment of multiple sclerosis. BMJ, 322 (7540):525-527.
2 Mitchell T. Wallin, et al. The prevalence of MS in the United States. Neurology. April 4, 2019. Available at https://n.neurology.org/content/92/10/e1029.
3 MS International Federation. What is MS? Available at http://www.msif.org/about-ms/what-is-ms/.
4 Simpson S, et al. (2011) Latitude is significantly associated with the prevalence of multiple sclerosis: a meta-analysis. J Neurol Neurosurg Psychiatry, 82(10):1132-1141.
5 National Institutes of Health-National Institute of Neurological Disorders and Stroke. (2015). Multiple Sclerosis: Hope Through Research. Available at: https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Multiple-Sclerosis-Hope-Through-Research.
6 Hemmett L, et al. (2004) What drives quality of life in multiple sclerosis? QJM, 97(10):671–6.
7 Souza A, et al. (2010) Multiple sclerosis and mobility-related assistive technology: systematic review of the literature. J Rehabil Res Dev, 47:213–223.
8 National Multiple Sclerosis Society. (2010). Gait or Walking Problems. Available at: http://www.nationalmssociety.org/NationalMSSociety/media/MSNationalFiles/Brochures/Brochure-Gait-or-Walking-Problems.pdf.
9 United States Department of Veterans Affairs. Visual Dysfunction in Multiple Sclerosis. Available at: http://www.va.gov/MS/Veterans/symptom_management/Visual_Dysfunction_in_Multiple_Sclerosis.asp
10 National Multiple Sclerosis Society. Bladder Problems. Available at: http://www.nationalmssociety.org/Symptoms-Diagnosis/MS-Symptoms/Bladder-Dysfunction
11 Siegert RJ, Abernethy DA. (2005). Depression in multiple sclerosis: a review. J Neurol Neurosurg Psychiatry, 76:469–475.
12 Lobentanz IS, et al. (2004). Factors influencing quality of life in multiple sclerosis patients: Disability, depressive mood, fatigue and sleep quality. Acta Neurologica Scandinavica, 110:6–13.
13 National Multiple Sclerosis Society. Types of MS. Available at http://www.nationalmssociety.org/What-is-MS/Types-of-MS.
14 Lublin F.D. et al. (2014). Defining the clinical course of multiple sclerosis. Neurology, 83(3),278-86.
15 National Multiple Sclerosis Society. Managing Relapses. Available at: http://www.nationalmssociety.org/Treating-MS/Managing-Relapses.
16 Erbayat A, et al. (2013). Reliability of classifying multiple sclerosis disease activity using magnetic resonance imaging in a multiple sclerosis clinic. JAMA Neurol, 70(3):338-44.