Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 7901 - 7950 OF 15190 RESULTS

The two-component sensor kinase KdpD is required for Salmonella typhimurium colonization of Caenorhabditis elegans and survival in macrophages
Cellular Microbiology, ISSN: 14625814 14625822
Rosanna A. Alegado; Chui-Yoke Chin; Denise M. Monack; Man-Wah Tan
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IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
Nature Immunology, ISSN: 15292908 15292916
Naruhisa Ota; Kit Wong; Patricia A. Valdez; Yan Zheng; Natasha K Crellin; Laurie Diehl; Wenjun Ouyang
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Potential errors in the volume of distribution estimation of therapeutic proteins composed of differently cleared components
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X 15738744
Wolfgang F. Richter; Hans Peter Grimm; Frank-Peter Theil
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Site-specific tryptophan oxidation induced by autocatalytic reaction of polysorbate 20 in protein formulation
Pharmaceutical Research, ISSN: 07248741 1573904X
Lam; William G. Lai; Edwin K. Chan; Victor Ling; Chung C. Hsu
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Effects of cell culture conditions on antibody N-linked glycosylation-what affects high mannose 5 glycoform
Biotechnology and Bioengineering, ISSN: 00063592 10970290
Efren Pacis; Marcella Yu; Jennifer Autsen; Robert Bayer; Feng Li
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Evaluation of dried blood spot sampling following cassette dosing in drug discovery
Bioanalysis, ISSN: 17576180 17576199
Xiaorong Liang; Lulu Yang; Leonid M. Berezhkovskiy; Bianca M. Liederer; Trung Nguyen; Wei Jia; Michelle G. Schweiger; Brian J. Dean; Yuzhong Deng
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Intracranial hypertension in pediatric patients treated with recombinant human growth hormone: Data from 25 years of the genentech National Cooperative Growth Study
Journal of Pediatric Endocrinology and Metabolism, ISSN: 0334018X 21910251
Richard Noto; Thomas J. Maneatis; James W. Frane; Kimberly Alexander; Barbara M. Lippe; Daniel A. Davis
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Sustained benefits from ranibizumab for macular edema following central retinal vein occlusion: Twelve-month outcomes of a phase III study
Ophthalmology, ISSN: 01616420 15494713
Peter A. Campochiaro; David M. Brown; Carl C. Awh; S. Young Lee; Sarah Gray; Namrata Saroj; Wendy Yee Murahashi; Roman G. Rubio
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Healthcare costs associated with bevacizumab and cetuximab in second-line treatment of metastatic colorectal cancer
Journal of Medical Economics, ISSN: 13696998 1941837X
Hongbo Yang; Andrew P. Yu; Eric Q. Wu; Yeun Mi Yim; Elaine B. Yu
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Erratum: A predictive model of therapeutic monoclonal antibody dynamics and regulation by the neonatal Fc receptor (FcRn) (Annals of Biomedical Engineering (2005) 33:11 (1640-1652) DOI: 10.1007/s10439-005-7410-3)
Annals of Biomedical Engineering, ISSN: 00906964 15739686
Gregory Z. Ferl; Anna H. Wu; Joseph J. Distefano III
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Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Lichuan Liu; Jason S Halladay; Young G. Shin; Susan C. Wong; Melis Coraggio; Hank La; Matthew Baumgardner; Hoa Le; Sashi Gopaul; Jason Boggs; Peter Kuebler; John C. Davis; X. Charlene Liao; Joseph W. Lubach; Alan Deese; C. Gregory Sowell; Kevin S. Currie; Wendy B. Young; S. Cyrus Khojasteh; Cornelis E. Hop; Harvey Wong
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Gut-derived factors promote neurogenesis of CNS-neural stem cells and nudge their differentiation to an enteric-like neuronal phenotype
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN: 01931857 15221547
Subhash Kulkarni; Bende Zou; Jesse E. Hanson; Maria-Adelaide Micci; Gunjan Tiwari; Laren Becker; Martin Kaiser; Xinmin Xie; Pankaj Jay Pasricha
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Overcoming challenges in WAVE bioreactors without feedback controls for pH and dissolved oxygen
Biotechnology Progress, ISSN: 87567938 15206033
Inn H. Yuk; Dinesh Baskar; Philip H. Duffy; Jenny Hsiung; Susan Leung; Andy Lin
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Lung gene expression in a rhesus allergic asthma model correlates with physiologic parameters of disease and exhibits common and distinct pathways with human asthma and a mouse asthma model
American Journal of Pathology, ISSN: 00029440 15252191
Abbas Alexander; Janet Jackman; Sherron L. Bullens; Sarah M. Davis; David F. Choy; Grazyna Fedorowicz; Martha Tan; Bao-Tran Truong; Meng; Laurie Diehl; Lisa A. Miller; Edward S. Schelegle; Dallas M. Hyde; Hilary F. Clark; Zora Modrusan; Joseph R. Arron; Lawren C. Wu
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Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus
PLoS Genetics, ISSN: 15537390 15537404
Deborah S. Cunninghame Graham; David L. Morris; Tushar Bhangale; Lindsey A. Criswell; Ann-Christine Syvänen; Lars Rönnblom; Timothy W. Behrens; Robert R. Graham; Timothy J. Vyse
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Regulation of interleukin-10 and interleukin-22 expression in T helper cells
Current Opinion in Immunology, ISSN: 09527915 18790372
Sascha Rutz; Wenjun Ouyang
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Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Diya Ren; Jian Zhang; Ross Pritchett; Hongbin Liu; Jennifer Kyauk; Jun Luo; Ashraf Amanullah
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Introductory perspective
Seminars in Immunology, ISSN: 10445323 10963618
Harinder Singh
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Development of tools and processes to improve treatment times in patients with febrile neutropenia
Clinical journal of oncology nursing, ISSN: 10921095 1538067X
Erika L. Hawley; Molly Loney; Michelle Wiece
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An observational study to validate the Satisfaction Measure of the Injection of Growth Hormone Therapy (SMIGHTy) questionnaire
Current Medical Research and Opinion, ISSN: 03007995 14734877
Richard R. Rubin; Peyrot; Catherine P. Metzinger; Yaping Xu; Barbara M. Lippe; Leah McCormack; Daniel Aaron Davis
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Regioselective synthesis of β-iodo-enamides and β-yn-enamides
Tetrahedron, ISSN: 00404020 14645416
Adele E. Pasqua; Lynne H. Thomas; James J. Crawford; Rodolfo Marquez
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Exploration of overloaded cation exchange chromatography for monoclonal antibody purification
Journal of Chromatography A, ISSN: 00219673 18733778
Hui F. Liu; Beth McCooey; Tiago Duarte; Deanna E. Myers; Terry Hudson; Ashraf Amanullah; Robert Van Reis; Kelley
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Immunoglobulin E receptor signaling and asthma
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Lawren C. Wu
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Lebrikizumab treatment in adults with asthma
New England Journal of Medicine, ISSN: 15334406 00284793
Jonathan Corren; Robert F. Lemanske Jr.; Nicola A. Hanania; Phillip Korenblat; Merdad V. Parsey; Joseph R. Arron; Harris; Heleen Scheerens; Lawren C. Wu; Zheng Su; Mosesova; Mark D. Eisner; Sean P. Bohen; Matthews
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A plasmablast biomarker for nonresponse to antibody therapy to CD20 in rheumatoid arthritis
Science Translational Medicine, ISSN: 19466234 19466242
Kasia Owczarczyk; Preeti Lal; Abbas Alexander; Kristen Wolslegel; Cécile T.J. Holweg; Wolfgang Dummer; Ariella Kelman; Paul Brunetta; Nicholas Lewin-Koh; Marco Sorani; Diane Leong; Fielder; David E. Yocum; Carole Ho; Ward Ortmann; Michael J. Townsend; Timothy W. Behrens
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Patterns of biologic agent utilization among patients with rheumatoid arthritis: A retrospective cohort study
BMC Musculoskeletal Disorders, ISSN: 14712474
Sarika Ogale; Hitraya; Henry J. Henk
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High-throughput, 384-well, LC-MS/MS CYP inhibition assay using automation, cassette-analysis technique and streamlined data analysis
Drug Metabolism Letters, ISSN: 18723128
Jason S Halladay; Erlie Marie Delarosa; Daniel Tran; Leslie Wang; Susan C. Wong; S. Cyrus Khojasteh
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Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Amitabha Chaudhuri; Xie; Becky Yang; Kaushiki Mahapatra; Jinfeng Liu; Scot A. Marsters; Sweta Bodepudi; Avi Ashkenazi
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USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma
Cell, ISSN: 10974172 00928674
Samuel A. Williams; Heather Maecker; French; Jinfeng Liu; Andrew Gregg; Leah B. Silverstein; Tim C. Cao; Richard A. D. Carano; Vishva M. Dixit
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Pyrazolopyridine inhibitors of B-Raf V600E. Part 2: Structure-activity relationships
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steve Wenglowsky; Kateri Ahrendt; Alexandre J. Buckmelter; Bainian Feng; Susan L. Gloor; Stefan Gradl; Jonas Grina; Joshua D. Hansen; Ellen R. Laird; Paul Lunghofer; Simon Mathieu; David Moreno; Bradley J. Newhouse; Li Ren; Tyler Risom; Joachim Rudolph; Jeongbeob Seo; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen
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A simple assay for 3-deoxy-D-manno-octulosonate cytidylyltransferase and its use as a pathway screen
Analytical Biochemistry, ISSN: 10960309 00032697
Li Yi; Melvin S. Velasquez; Tod P. Holler; Ronald W. Woodard
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The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1
Cell Cycle, ISSN: 15514005 15384101
Elizabeth Fidalgo Da Silva; Shora B. Ansari; Jiamila Maimaiti; Elizabeth A. Barnes; Monica Kong-Beltran; Daniel J. Donoghue; Lisa A. Porter
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Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
Human Molecular Genetics, ISSN: 14602083 09646906
Yi Yu; Tushar Bhangale; Jesen Fagerness; Stephan Ripke; Gudmar Thorleifsson; Perciliz L. Tan; Eric H. Souied; Andrea J. Richardson; Joanna E. Merriam; Gabriëlle H.S. Buitendijk; Robyn Reynolds; Soumya Raychaudhuri; Kimberly A. Chin; Lucia Sobrin; Evangelos Evangelou; Phil H Lee; Aaron Y. Lee; Nicolas Leveziel; Donald J. Zack; Betsy Campochiaro; Peter A. Campochiaro; R. Theodore Smith; Gaetano R. Barile; Robyn H. Guymer; Ruth E. Hogg; Usha Chakravarthy; Luba D. Robman; Omar Gustafsson; Haraldur Sigurdsson; Ward Ortmann; Timothy W. Behrens; Kari Stefansson; André G. Uitterlinden; Cornelia M. Van Duijn; Johannes R. Vingerling; Caroline C.W. Klaver; Rando Allikmets; Milam A. Brantley Jr.; Paul N. Baird; Nicholas Katsanis; Unnur Thorsteinsdottir; John P.A. Ioannidis; Mark J. Daly; Robert R. Graham; Johanna M. Seddon
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Access to saturated fused pyrimidine derivatives via a flexible N -vinyl tertiary enamide synthesis
Synlett, ISSN: 09365214 14372096
Anthony A. Estrada; Joseph P. Lyssikatos; Frederic St-Jean; Philippe Bergeron
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Phage display of tissue inhibitor of metalloproteinases-2 (TIMP-2): Identification of selective inhibitors of collagenase-1 (metalloproteinase 1 (MMP-1))
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Harinath Bahudhanapati; Yingnan Zhang; Sachdev S. Sidhu; Keith Brew
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Purification Process Design and the Influence of Product and Technology Platforms
Comprehensive Biotechnology, Second Edition,
Chris Dowd; Kelley
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Disposable Bioreactors
Comprehensive Biotechnology, Second Edition,
Oosterhuis; Terry Hudson; D'Avino; Zijlstra; Ashraf Amanullah
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Process Validation
Comprehensive Biotechnology, Second Edition,
David H. Reifsnyder; Nathan McKnight; Kelley
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DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
Journal of Cell Biology, ISSN: 00219525 15408140
Arundhati Sengupta Ghosh; Bei Wang; Christine D. Pozniak; Mark Chen; Ryan J. Watts; Joe Lewcock
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The interleukin-17 cytokine family: Critical players in host defence and inflammatory diseases
Immunology, ISSN: 00192805 13652567
Rajita Pappu; Vladimir Ramirez-Carrozzi; Arivazhagan Sambandam
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Conference report: The AAPS national biotechnology conference
Therapeutic Delivery, ISSN: 20415990 20416008
Margaret Kenrick
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Bounds for an estimate of the optimal backward error for linear least squares problems
International Journal of Computer Mathematics, ISSN: 00207160 10290265
Zheng Su
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2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections
Bioanalysis, ISSN: 17576180 17576199
Fabio Garofolo; Mario Rocci; Isabelle Dumont; Suzanne Martinez; Steve Lowes; Eric Woolf; Peter Van Amsterdam; Surendra Bansal; Ariadna Cristina Gomes Barra; Ronald Bauer; Brian Booth; Montserrat Carrasco-Triguero; Binodh DeSilva; John Dunn; Keith Gallicano; Dominique Gouty; Stacy Ho; Richard Hucker; Mohammed Jemal; Noriko Katori; Olivier Le Blaye; Jean W. Lee; Wenkui Li; Steve Michael; Corey Nehls; Robert Nicholson; Eric Ormsby; Daniel Tang; Viswanathan; Russell Weiner; Graeme Young
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PPM1H Is a p27 phosphatase implicated in trastuzumab resistance
Cancer Discovery, ISSN: 21598274 21598290
Si Tuen Lee-Hoeflich; Thinh Q. Pham; Dowbenko; Xander Munroe; James Lee; Li Li; Wei Zhou; Matthias Peter; Kanan Pujara; Stinson; Sara M. Chan; Jeffrey Eastham-Anderson; Ajay Pandita; Somasekar Seshagiri; Klaus P. Hoeflich; Gulisa Turashvili; Karen A. Gelmon; Samuel A. Aparicio; David P. Davis; Mark X. Sliwkowski; Howard M. Stern
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The science of project management: Project controls systems integration
Pharmaceutical Engineering, ISSN: 02738139
Frederick Cramer; Susanne Keller; Christopher Law; Thomas Shih; Britton L. Wolf
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A hybrid approach to predicting events in clinical trials with time-to-event outcomes
Contemporary Clinical Trials, ISSN: 15517144 15592030
Liang Fang; Zheng Su
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Randomized, placebo-controlled clinical trial of an aerosolized β2-agonist for treatment of acute lung injury
American Journal of Respiratory and Critical Care Medicine, ISSN: 1073449X 15354970
Michael A. Matthay; Roy G. Brower; Shannon Carson; Ivor S. Douglas; Mark D. Eisner; Duncan Hite; Steven Holets; Richard H. Kallet; Kathleen D. Liu; Neil MacIntyre; Marc Moss; David Schoenfeld; Jay S. Steingrub; B. Taylor Thompson
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Dextran sieving test for characterization of virus filtration membranes
Journal of Membrane Science, ISSN: 03767388 18733123
Meisam Bakhshayeshi; Dharmesh M. Kanani; Amit Mehta; Robert Van Reis; Ralf Kuriyel; Nigel B. Jackson; Andrew Zydney
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Cross talk between ubiquitination and demethylation
Molecular and Cellular Biology, ISSN: 02707306 10985549
Xiaodong Huang; Vishva M. Dixit
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Magnetic resonance imaging in rheumatoid arthritis clinical trials: Emerging patterns based on recent experience
Journal of Rheumatology, ISSN: 0315162X 14992752
Charles G. Peterfy; Peter Countryman; Annarita Gabriele; Tim Shaw; Andrew Anisfeld; Wayne Tsuji; Ewa Olech; Norman B. Gaylis; Philip G. Conaghan; Vibeke Strand; Julie DiCarlo
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