Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8001 - 8050 OF 15190 RESULTS

ExpressionPlot: A web-based framework for analysis of RNA-Seq and microarray gene expression data
Genome Biology, ISSN: 14747596 1474760X
Brad A. Friedman; Tom Maniatis
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Toso regulates the balance between apoptotic and nonapoptotic death receptor signaling by facilitating RIP1 ubiquitination
Blood, ISSN: 15280020 00064971
Xuan-Hung Nguyen; Philipp A. Lang; Karl S. Lang; Dieter Adam; Gulnar Fattakhova; Niko Föger; Mohammad Azhar Kamal; Patricia Prilla; Sabine Mathieu; Christina Wagner; Tak W. Mak; Andrew A. Chan; Kyeong-Hee Lee
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Distinct apoptotic signaling characteristics of the anti-CD40 monoclonal antibody dacetuzumab and rituximab produce enhanced antitumor activity in non-Hodgkin lymphoma
Clinical Cancer Research, ISSN: 10780432 15573265
Timothy S. Lewis; Renee S. McCormick; Kim Emmerton; Jeffrey Lau; Shang-Fan Yu; Julie A. McEarchern; Iqbal S. Grewal; Che-Leung Law
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Pharmacokinetic-pharmacodynamic analysis of vismodegib in preclinical models of mutational and ligand-dependent Hedgehog pathway activation
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Bruno Alicke; Kristina West; Patricia Pacheco; Hank La; Thomas Januario; Robert Yauch; Frederic J. De Sauvage; Stephen Gould
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Modulation of the thermodynamic stability of proteins by polyols: Significance of polyol hydrophobicity and impact on the chemical potential of water
International Journal of Pharmaceutics, ISSN: 03785173 18733476
Vineet Kumar; Ravi Chari; Vikas Sharma; Devendra S. Kalonia
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Central nervous system metastases in patients with HER2-positive metastatic breast cancer: Incidence, treatment, and survival in patients from registHER
Clinical Cancer Research, ISSN: 10780432 15573265
Adam Brufsky; Musa Mayer; Hope S. Rugo; Peter A. Kaufman; Elizabeth Tan-Chiu; Debasish Tripathy; Iulia Cristina Tudor; Lisa I. Wang; Melissa Brammer; Mona Shing; Marianne Ulcickas Yood; Denise A. Yardley
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Determination of unbound vismodegib (GDC-0449) concentration in human plasma using rapid equilibrium dialysis followed by solid phase extraction and high-performance liquid chromatography coupled to mass spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 15700232 1873376X
Yuzhong Deng; Harvey Wong; Richard A. Graham; Wenbin Liu; Heuy-Shin Shen; Yao Shi; Laixin Wang; Meng; Vikram Malhi; Xiao Ding; Brian J. Dean
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Modulation of inflammasome pathways by bacterial and viral pathogens
Journal of Immunology, ISSN: 00221767 15506606
Lamkanfi; Vishva M. Dixit
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Increased rheumatoid factor interference observed during immunogenicity assessment of an Fc-engineered therapeutic antibody
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
James Araujo; Marcel Zocher; Kristin Wallace; Kun Peng; Saloumeh Kadkhodayan Fischer
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Recommendations for the validation of cell-based assays used for the detection of neutralizing antibody immune responses elicited against biological therapeutics
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085 1873264X
Shalini Gupta; Viswanath Devanarayan; Deborah Finco-Kent; George R. Gunn; Susan Kirshner; Richards; Bonita Rup; An Song; Subramanyam
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Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jenny Yao; Xiumin Wu; Guanglei Zhuang; Ian Kasman; Tobias Vogt; Vernon T. Phan; Masabumi Shibuya; Napoleone Ferrara; Carlos Bais
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Development and evolution of the human neocortex
Cell, ISSN: 10974172 00928674
Jan H. Lui; David V. Hansen; Arnold R. Kriegstein
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Efflux of Drugs via Transporters-The Antiabsorption Pathway
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications,
Jae H. Chang; James A. Uchizono; Miki Susanto Park
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Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways
Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications,
Miki Susanto Park; Jae H. Chang
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Investigating liquid leak from pre-filled syringes upon needle shield removal: Effect of air bubble pressure
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Edwin K. Chan; Maa; David E. Overcashier; Chung C. Hsu
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Fewer recurrent infections of C. difficile seen with fidaxomicin. This new class of antibiotic--the macrocycles--has a greater sustained response against re-infection than vancomycin.
Managed Care, ISSN: 10623388
Thomas Morrow
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An improved method for visualizing the morphology of lyophilized product cakes
PDA Journal of Pharmaceutical Science and Technology, ISSN: 10797440
Philippe Lam; Thomas W. Patapoff
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Structure-based design of thienobenzoxepin inhibitors of PI3-kinase
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Michael Siu; Richard Goldsmith; Alan G. Olivero; Steven Do; Burdick; Timothy P. Heffron; Jennafer Dotson; Daniel P. Sutherlin; Bing-Yan Zhu; Vickie Tsui; Hoa Le; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Steve Sideris; Wiesmann; Ping Wu
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Biopharmaceutical manufacturing using blow-Fill-Seal Technology
BioPharm International, ISSN: 1542166X 19391862
Wei Liu; Philippe Lam; Scott Faulhaber; Samir Sane
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Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus
Arthritis and Rheumatism, ISSN: 00043591 15290131
Paula S. Ramos; Adrienne H. Williams; Julie T. Ziegler; Mary E. Comeau; Richard T. Guy; Christopher J. Lessard; He Li; Jeffrey C. Edberg; Raphael Zidovetzki; Lindsey A. Criswell; Patrick M. Gaffney; Deborah S. Cunninghame Graham; Robert R. Graham; Jennifer A. Kelly; Kenneth M. Kaufman; Elizabeth E. Brown; Graciela S. Alarcõn; Michelle Petri; John D. Reveille; Gerald McGwin; Luis M. Vilá; Robert P. Kimberly; Chaim O. Jacob; Timothy J. Vyse; Betty P. Tsao; John B. Harley; Robert P. Kimberly; Marta E. Alarcón-Riquelme; Carl D. Langefeld; Kathy L. Moser
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Trastuzumab-DM1 (T-DM1) retains all the mechanisms of action of trastuzumab and efficiently inhibits growth of lapatinib insensitive breast cancer
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Teemu T. Junttila; Guangmin Li; Kathryn Parsons; Gail L. Phillips; Mark X. Sliwkowski
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Balancing multiple baseline characteristics in randomized clinical trials
Contemporary Clinical Trials, ISSN: 15517144 15592030
Zheng Su
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Antiarthritis effect of a novel Bruton's Tyrosine Kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/ pharmacodynamic modeling: Relationships between inhibition of BTK phosphorylation and efficacy
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Lichuan Liu; Julie Di Paolo; Jim Barbosa; Hong Rong; Karin Reif; Harvey Wong
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A class of designs for phase I cancer clinical trials combining Bayesian and likelihood approaches
Journal of Applied Statistics, ISSN: 02664763 13600532
Zheng Su
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Structure determination by MALDI-IRMPD mass spectrometry and exoglycosidase digestions of O-linked oligosaccharides from Xenopus borealis egg jelly
Glycobiology, ISSN: 09596658 14602423
Bensheng Li; Scott C. Russell; Jinhua Zhang; Jerry L. Hedrick; Carlito B. Lebrilla
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Preview: A program for surveying shotgun proteomics tandem mass spectrometry data
Analytical Chemistry, ISSN: 00032700
Yong J. Kil; Christopher Becker; Wendy N. Sandoval; David Goldberg; Marshall Bern
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Establishing a link between amino acid sequences and self-associating and viscoelastic behavior of two closely related monoclonal antibodies
Pharmaceutical Research, ISSN: 07248741 1573904X
Sandeep Yadav; Alavattam Sreedhara; Sonoko Kanai; Jun Liu; Samantha Lien; Henry B. Lowman; Devendra S. Kalonia; Steven J. Shire
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Danoprevir monotherapy decreases inflammatory markers in patients with chronic hepatitis C virus infection
Antimicrobial Agents and Chemotherapy, ISSN: 00664804 10986596
Caralee J. Schaefer; Karl Kossen; Sharlene R. Lim; Jiing-Huey Lin; Lin Pan; Williamson Bradford; Patrick F. Smith; Scott D. Seiwert
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Rosettascripts: A scripting language interface to the Rosetta Macromolecular modeling suite
PLoS ONE, ISSN: 19326203
Sarel J. Fleishman; Andrew Leaver-Fay; Jacob E. Corn; Eva-Maria Strauch; Sagar D. Khare; Nobuyasu Koga; Justin Ashworth; Paul Murphy; Florian Richter; Gordon Lemmon; Meiler; David Baker
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Improved survival with vemurafenib in melanoma with BRAF V600E mutation
New England Journal of Medicine, ISSN: 15334406 00284793
Paul B. Chapman; Axel Hauschild; Caroline Robert; John B. Haanen; Paolo A. Ascierto; James Larkin; Reinhard Dummer; Claus Garbe; Alessandro Testori; Michele Maio; Hogg; Paul Lorigan; Celeste Lebbe; Thomas Jouary; Dirk Schadendorf; Antoni Ribas; Steven J. O'Day; Jeffrey A. Sosman; John M. Kirkwood; Alexander M. M. Eggermont; Brigitte Dréno; Keith B. Nolop; Jiang Li; Betty Nelson; Jeannie Hou; Richard J. Lee; Keith Flaherty; McArthur
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The tubby family proteins
Genome Biology, ISSN: 14747596 1474760X
Saikat Mukhopadhyay; Peter K Jackson
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Regulation of angiogenesis by a non-canonical Wnt - Flt1 pathway in myeloid cells
Nature, ISSN: 00280836 14764687
James A. Stefater III; Ian Lewkowich; Sujata Rao; Giovanni Mariggi; April C. Carpenter; Adam R. Burr; Jieqing Fan; Rieko Ajima; Jeffery D. Molkentin; Bart O. Williams; Marsha Wills-Karp; Jeffrey W. Pollard; Terry Yamaguchi; Napoleone Ferrara; Holger Gerhardt; Richard Lang
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Innate immunity: Unfolding the neuro-immuno connections
Current Biology, ISSN: 09609822
Man-Wah Tan
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Retrospective study of the effect of disease progression on patient reported outcomes in HER-2 negative metastatic breast cancer patients
Health and Quality of Life Outcomes, ISSN: 14777525
Mark S. Walker; Murad Hasan; Yeun Mi Yim; Elaine B. Yu; Edward J. Stepanski; Lee S. Schwartzberg
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Confirmatory Immunogenicity Assays
Detection and Quantification of Antibodies to Biopharmaceuticals: Practical and Applied Considerations,
Eric Wakshull; Daniel A. Coleman
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TWEAK induces apoptosis through a death-signaling complex comprising receptor-interacting protein 1 (RIP1), Fas-associated Death Domain (FADD), and caspase-8
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Aminah Ikner; Avi Ashkenazi
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COP1 is a tumour suppressor that causes degradation of ETS transcription factors
Nature, ISSN: 00280836 14764687
Alberto C. Vitari; Kevin G. Leong; Kim Newton; Cindy Yee; Karen M. O'Rourke; Jinfeng Liu; Lilian Phu; Rajesh Vij; Ron Ferrando; Suzana Couto; Sankar Mohan; Ajay Pandita; Hongo; David Arnott; Ingrid E. Wertz; Gao; French; Vishva M. Dixit
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TRPS1 targeting by miR-221/222 promotes the epithelial-to-mesenchymal transition in breast cancer
Science Signaling, ISSN: 19450877 19379145
Susanna Y. Stinson; Lackner; Alex T. Adai; Nancy Yu; Hyo-Jin Kim; Carol O'Brien; Jill M. Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Thomas Januario; Robert J. Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard M. Stern; Søren Warming; Frederic J. De Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan
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Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
Science, ISSN: 00368075 10959203
Yonghao Yu; Sang-Oh Yoon; George Poulogiannis; Qian Yang; Xiaoju Max Ma; Judit Villén; Neil Kubica; Gregory R. Hoffman; Lewis C. Cantley; Steven P. Gygi; John Blenis
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VEGF Mediates Commissural Axon Chemoattraction through Its Receptor Flk1
Neuron, ISSN: 08966273 10974199
Carmen Ruiz de Almodovar; Pierre J. Fabre; Ellen Knevels; Cathy Coulon; Inmaculada Segura; Patrick C. G. Haddick; Liesbeth Aerts; Nicolas Delattin; Geraldine Strasser; Won-Jong Oh; Christian Lange; Stefan Vinckier; Jody Haigh; Coralie Fouquet; Chenghua Gu; Kari Alitalo; Valerie Castellani; Marc Tessier-Lavigne; Alain Chedotal; Frédéric Charron; Peter Carmeliet
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The arf GAP CNT-2 regulates the apoptotic fate in C. elegans asymmetric neuroblast divisions
Current Biology, ISSN: 09609822
Aakanksha Singhvi; Jerome Teuliere; Karla Talavera; Shaun Cordes; Guangshuo Ou; Ronald D. Vale; Brinda C. Prasad; Clark; Gian Garriga
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Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Weiwei Chen; Tracy Tzu-Ling Tang; Jeffrey Eastham-Anderson; Debra Dunlap; Bruno Alicke; Michelle Nannini; Stephen Gould; Robert Yauch; Zora Modrusan; Kelly J. DuPree; Darbonne; Greg D. Plowman; Frederic J. De Sauvage; Christopher A. Callahana
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Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Abigail I. Nash; Reginald McNulty; Mary Elizabeth Shillito; Trevor E. Swartz; Roberto A. Bogomolni; Hartmut Luecke; Kevin H. Gardner
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A high throughput approach to purifying chiral molecules using 3μm analytical chiral stationary phases via supercritical fluid chromatography
Journal of Chromatography A, ISSN: 00219673
Chris Hamman; Mengling Wong; Michael Hayes; Paul Gibbons
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Improved synthesis of γ-lactones from cyclopropyl cyanoesters
Synthetic Communications, ISSN: 00397911 15322432
Nandini C. Patel; Jacob B. Schwarz; Khondaker Islam; Whitney Miller; Tuan P. Tran; Yunjing Wei
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Immunology: In command of commensals
Nature, ISSN: 00280836 14764687
Menno Van Lookeren Campagne; Vishva M. Dixit
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Substrate binding disrupts dimerization and induces nucleotide exchange of the chloroplast GTPase Toc33
Biochemical Journal, ISSN: 02646021 14708728
Mislav Oreb; Anja Höfle; Patrick Koenig; Maik S. Sommer; Irmgard Sinning; Fei Wang; Ivo Tews; Danny J. Schnell; Enrico Schleiff
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Characterization of xenobiotic-induced hepatocellular enzyme induction in rats: Anticipated thyroid effects and unique pituitary gland findings
Toxicologic Pathology, ISSN: 01926233 15331601
Tanja S. Zabka; Mark Fielden; Rosario Garrido; Jianhua Tao; Adrian J. Fretland; Jennifer Fretland; Mudher Albassam; Thomas Singer; Kolaja
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Streamlining downstream process development
BioProcess International, ISSN: 15426319
Brian Kluck; Binh Thai; Jim Furey; Dennis Annarelli
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Treatment of chronic hepatitis C patients with the NS3/4A protease inhibitor danoprevir (ITMN-191/RG7227) leads to robust reductions in viral RNA: A phase 1b multiple ascending dose study
Journal of Hepatology, ISSN: 01688278 01688278
Nicole Forestier; Dominique Larrey; Dominique Guyader; Marcellin; Régine Rouzier; Alain Patat; Patrick F. Smith; Williamson Bradford; Steven Porter; Lawrence Blatt; Scott D. Seiwert; Stefan Zeuzem
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