Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 8201 - 8250 OF 15190 RESULTS

February 15, 2011

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Alexandre J. Buckmelter; Li Ren; Ellen R. Laird; Bryson Rast; Greg Miknis; Steve Wenglowsky; Stephen Schlachter; Michael Welch; Eugene Tarlton; Jonas Grina; Joseph P. Lyssikatos; Barbara J. Brandhuber; Tony Morales; Nikole Randolph; Guy Vigers; Matthew Martinson; Michele Callejo

February 15, 2011

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Christopher J. Westlake; Lisa M. Baye; Maxence V. Nachury; Kevin J. Wright; Karen E. Ervin; Lilian Phu; Cecile Chalouni; John S. Beck; Donald S. Kirkpatrick; Diane C. Slusarski; Val C. Sheffield; Richard H. Scheller; Peter K Jackson

February 14, 2011

Population pharmacokinetic evaluation with external validation and bayesian estimator of voriconazole in liver transplant recipients

Clinical Pharmacokinetics, ISSN: 03125963 11791926

Kelong Han; Robert Bies; Heather Johnson; Blair Capitano; Raman Venkataramanan

February 11, 2011

Menadione degrades the optical quality and mitochondrial integrity of bovine crystalline lenses

Molecular Vision, ISSN: 10900535

Kenneth W. Olsen; Vlad Bantseev; Vivan Choh

February 10, 2011

A general asymmetric synthesis of phenylglycinols

Tetrahedron Asymmetry, ISSN: 09574166 1362511X

Xingang Pan; Liangbin Jia; Xuejian Liu; Haikuo Ma; Wenqian Yang; Jacob B. Schwarz

February 10, 2011

Do we need to optimize plasma protein and tissue binding in drug discovery?

Current Topics in Medicinal Chemistry, ISSN: 15680266

Xingrong Liu; Cuiping Chen; Cornelis E. Hop

February 9, 2011

Tree pruner: An efficient tool for selecting data from a biased genetic database

BMC Bioinformatics, ISSN: 14712105

Mohan Krishnamoorthy; Pragneshkumar Patel; Mira Dimitrijevic; Jonathan Dietrich; Margaret Green; Catherine Macken

February 9, 2011

Differences in reversion of resistance mutations to wild- type under structured treatment interruption and related increase in replication capacity

PLoS ONE, ISSN: 19326203

Agnes C. Paquet; John Baxter; Jodi Weidler; Yolanda S. Lie; Jody Lawrence; Rose Kim; Michael Bates; Eoin Coakley; Colombe Chappey

February 3, 2011

Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay

PLoS ONE, ISSN: 19326203

Rajiv Dua; Jianhuan Zhang; Gordon Parry; Elicia M. Penuel

February 1, 2011

TRAPing a new gene for autoimmunity

Nature Genetics, ISSN: 10614036 15461718

Timothy W. Behrens; Robert R. Graham

February 1, 2011

TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro

PLoS ONE, ISSN: 19326203

Christina Menke; Tatiana Goncharov; Lubna Qamar; Christopher Korch; Heide L. Ford; Kian Behbakht; Andrew Thorburn

February 1, 2011

Laminin-332 cleavage by matriptase alters motility parameters of prostate cancer cells

Prostate, ISSN: 02704137 10970045

Manisha Tripathi; Alka A. Potdar; Hironobu Yamashita; Brandy Weidow; Peter T. Cummings; Daniel Kirchhofer; Vito Quaranta

February 1, 2011

The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling

Developmental Dynamics, ISSN: 10588388 10970177

Sangho Yu; Dianna Crawford; Takatoshi Tsuchihashi; Timothy W. Behrens; Deepak Srivastava

February 1, 2011

A new regulatory switch in a JAK protein kinase

Proteins: Structure, Function and Bioinformatics, ISSN: 08873585 10970134

Vickie Tsui; Paul Gibbons; Ultsch; Kyle Mortara; Christine Chang; Wade S. Blair; Rebecca Pulk; Mark S. Stanley; Melissa A. Starovasnik; David Williams; Maria Lamers; Phillip Leonard; Steven Magnuson; Jun Liang; Eigenbrot

February 1, 2011

Influences of aortic motion and curvature on vessel expansion in murine experimental aneurysms

Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN: 10795642

Craig J. Goergen; Junya Azuma; Kyla N. Barr; Lars Magdefessel; Dara Y. Kallop; Alvin Gogineni; Amarjeet Grewall; Robby M. Weimer; Andrew J. Connolly; Ronald L. Dalman; Charles A. Taylor; Philip S. Tsao; Joan M. Greve

February 1, 2011

Patterns of progression in patients with recurrent glioblastoma treated with bevacizumab

Neurology, ISSN: 00283878 1526632X

Whitney B. Pope; Qi Xia; Virginia Paton; Asha Das; Julie Hambleton; Kim; Huo; Brown; Goldin; Timothy Cloughesy

February 1, 2011

From the authors

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Mark D. Eisner

February 1, 2011

Paper Covers Rock: In Search of the e-record Model

Law and Critique, ISSN: 09578536 15728617

Jacques Mourrain

February 1, 2011

Budget impact of erlotinib for maintenance therapy in advanced non-small cell lung cancer

Journal of Medical Economics, ISSN: 13696998

Josh J. Carlson; Wong; David L. Veenstra; Carolina Reyes

February 1, 2011

Bleeding events in bevacizumab-treated cancer patients who received full-dose anticoagulation and remained on study

British Journal of Cancer, ISSN: 00070920 15321827

Natasha Leighl; Bennouna; Jing Yi; Moore; Julie Hambleton; Herbert Hurwitz

February 1, 2011

The transcriptional diversity of 25 Drosophila cell lines

Genome Research, ISSN: 10889051 15495469

Lucy Cherbas; Aarron T. Willingham; Dayu Zhang; Li Yang; Yi Zou; Brian D. Eads; Joseph W. Carlson; Jane M. Landolin; Philipp Kapranov; Jacqueline Dumais; Anastasia Samsonova; Jeong-Hyeon Choi; Johnny Roberts; Carrie A. Davis; Haixu Tang; Marijke J. Van Baren; Srinka Ghosh; Alexander Dobin; Kim Bell; Wei Lin; Laura Langton; Michael O. Duff; Aaron E. Tenney; Chris Zaleski; Michael R. Brent; Roger A. Hoskins; Thomas C. Kaufman; Justen Andrews; Brenton R. Graveley; Norbert Perrimon; Susan E. Celniker; Thomas R. Gingeras; Peter Cherbas

February 1, 2011

Resurrection of a clinical antibody: Template proteogenomic de novo proteomic sequencing and reverse engineering of an anti-lymphotoxin-α antibody

Proteomics, ISSN: 16159853 16159861

Natalie E. Castellana; Krista McCutcheon; Victoria Pham; Kristin Harden; Allen Nguyen; Judy Young; Adams; Kurt A. Schroeder; David Arnott; Vineet Bafna; Jane L. Grogan; Jennie R. Lill

February 1, 2011

A method for removing the brain and spinal cord as one unit from adult mice and rats

Lab Animal, ISSN: 00937355 15484475

Heather S. Kennedy; Floresita Puth; Marjie Van Hoy; Claire E. Le Pichon

February 1, 2011

Harnessing dendritic cells for immunotherapy

Seminars in Immunology, ISSN: 10445323

Lélia Delamarre; Ira Mellman

February 1, 2011

Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures

Protein Science, ISSN: 09618368 1469896X

Andreas Kuglstatter; April Wong; Stan Tsing; Simon W. Lee; Yan Lou; Armando G. Villaseñor; J. Michael Bradshaw; David Shaw; Jim W. Barnett; Michelle F. Browner

February 1, 2011

Effect of electrostatic spray on human pulmonary epithelial cells

Journal of Electrostatics, ISSN: 03043886

Michelle G. Zeles-Hahn; Yvonne Lentz; Thomas J. Anchordoquy; Corinne S. Lengsfeld

February 1, 2011

Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Sunaga; David S. Shames; Girard; Michael Peyton; Larsen; Imai; Junichi Soh; Sato; Noriko Yanagitani; Kaira; Yang Xie; Adi Gazdar; Mori; Minna

February 1, 2011

Effects of omalizumab on changes in pulmonary function induced by controlled cat room challenge

Journal of Allergy and Clinical Immunology, ISSN: 00916749

Jonathan Corren; Robert A. Wood; Deepen Patel; Jin Zhu; Ashley Yegin; Gitika Dhillon; James E. Fish

February 1, 2011

Advances in the assessment and control of the effector functions of therapeutic antibodies

Nature Reviews Drug Discovery, ISSN: 14741776 14741784

Xu-Rong Jiang; An Song; Svetlana Bergelson; Thomas Arroll; Bhavin S. Parekh; Kimberly May; Shan Chung; Robert Strouse; Mire-Sluis; Mark Schenerman

February 1, 2011

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase i study

Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535

Zheng; Heleen Scheerens; John C. Davis; Rong Deng; Saloumeh Kadkhodayan Fischer; Cynthia Woods; Fielder; Stefanich

February 1, 2011

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways

Journal of Immunology, ISSN: 00221767 15506606

David F. Choy; Barmak Modrek; Abbas Alexander; Sarah K. Kummerfeld; Hilary F. Clark; Lawren C. Wu; Grazyna Fedorowicz; Zora Modrusan; John V. Fahy; Prescott G. Woodruff; Joseph R. Arron

February 1, 2011

Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes

PLoS Genetics, ISSN: 15537390 15537404

Kimberly E. Taylor; Sharon A. Chung; Robert R. Graham; Ward Ortmann; Annette T. Lee; Carl D. Langefeld; Chaim O. Jacob; M. Ilyas Kamboh; Marta E. Alarcón-Riquelme; Betty P. Tsao; Kathy L. Moser; Patrick M. Gaffney; John B. Harley; Michelle Petri; Manzi; Peter K. Gregersen; Timothy W. Behrens; Lindsey A. Criswell

February 1, 2011

The quality product steward model: The genentech approach

BioPharm International, ISSN: 1542166X

Zhengyu Dong; Sharon Ma; Feuerhelm

February 1, 2011

Extractables and leachables

BioProcess International, ISSN: 15426319

Mire-Sluis; Stacey Ma; Ingrid Markovic; Lorna McLeod

January 30, 2011

Well differentiated follicular thyroid neoplasia: Impact of molecular and technological advances on detection, monitoring and treatment

Molecular and Cellular Endocrinology, ISSN: 03037207

Andrew G. Gianoukakis; Silvana M. Giannelli; Wael A. Salameh; Laron W. McPhaul

January 27, 2011

PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis

Oncogene, ISSN: 09509232 14765594

Bender; Opel; Naumann; Kappler; Lori S. Friedman; Von Schweinitz; Debatin; Fulda

January 26, 2011

Deep RNA sequencing analysis of readthrough gene fusions in human prostate adenocarcinoma and reference samples

BMC Medical Genomics, ISSN: 17558794

Serban Nacu; Yuan; Zhengyan Kan; Deepali Bhatt; Rivers; Stinson; Brock A. Peters; Zora Modrusan; Kenneth Jung; Somasekar Seshagiri; Thomas D Wu

January 25, 2011

Validation of a pH gradient-based ion-exchange chromatography method for high-resolution monoclonal antibody charge variant separations

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Jennifer C. Rea; G. Tony Moreno; Yun Lou; Dell Farnan

January 25, 2011

Comparison of competitive ligand-binding assay and bioassay formats for the measurement of neutralizing antibodies to protein therapeutics

Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085

Deborah Finco-Kent; Daniel Baltrukonis; Adrienne Clements-Egan; Kathy Delaria; George R. Gunn; John Lowe; Mauricio Maia; Teresa Wong

January 25, 2011

Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Zhenglei Pei; Bei Wang; Gang Chen; Motoshi Nagao; Masato Nakafuku; Kenneth Campbell

January 21, 2011

Development of a second-generation, highly efficient manufacturing route for the HIV integrase inhibitor raltegravir potassium

Organic Process Research and Development, ISSN: 10836160 1520586X

Guy R. Humphrey; Philip J. Pye; Yong-Li Zhong; Remy Angelaud; David Askin; Kevin M. Belyk; Peter E. Maligres; Danny E. Mancheno; Ross A. Miller; Robert A. Reamer; Steven A. Weissman

January 19, 2011

ACS chemical neuroscience spotlight on CEP-1347

ACS Chemical Neuroscience, ISSN: 19487193

Zachary K. Sweeney; Joe Lewcock

January 18, 2011

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

Developmental Cell, ISSN: 15345807 18781551

Alexander W. Koch; Thomas Mathivet; Bruno Larrivee; Raymond K. Tong; Joe Kowalski; Laurence Pibouin-Fragner; Karine Bouvrée; Scott Stawicki; Nicholes; Nisha Rathore; Suzie J. Scales; Luis; Raquel del Toro; Catarina Freitas; Christiane Bréant; Annie Michaud; Pierre Corvol; Jean-Léon Thomas; Yan Wu; Franklin V. Peale Jr.; Ryan J. Watts; Marc Tessier-Lavigne; Anil Bagri; Anne Eichmann

January 18, 2011

An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells

Cancer Cell, ISSN: 18783686 15356108

Nicholas S. Wilson; Becky Yang; Annie Yang; Stefanie Loeser; Scot A. Marsters; David Lawrence; Yun Li; Pitti; Klara Totpal; Sharon Fong Yee; Ross; Jean-Michel Vernes; Yanmei Lu; Cam Adams; Rienk Offringa; Bob Kelley; Sarah G. Hymowitz; Dylan Daniel; Meng; Avi Ashkenazi

January 17, 2011

IL-27 promotes T cell-dependent colitis through multiple mechanisms

Journal of Experimental Medicine, ISSN: 00221007 15409538

Jennifer Cox; Noelyn Kljavin; Nandhini Ramamoorthi; Laurie Diehl; Marcel Batten; Nico Ghilardi

January 15, 2011

Impact of exploratory biomarkers on the treatment effect of bevacizumab in metastatic breast cancer

Clinical Cancer Research, ISSN: 10780432 15573265

Adrian M. Jubb; Kathy Miller; Hope S. Rugo; Adrian L. Harris; Dafeng Chen; Reimann; Melody A. Cobleigh; Maike Schmidt; Virginia K. Langmuir; Kenneth J. Hillan; Daniel S. Chen; Koeppen

January 15, 2011

Immune complex-mediated cell activation from systemic lupus erythematosus and rheumatoid arthritis patients elaborate different requirements for IRAK1/4 kinase activity across human cell types

Journal of Immunology, ISSN: 00221767 15506606

Eugene Y. Chiang; Xin Yu; Jane L. Grogan

January 15, 2011

P53 transactivation is involved in the antiproliferative activity of the putative tumor suppressor RBM5

International Journal of Cancer, ISSN: 00207136 10970215

Takahiko Kobayashi; Junich Ishida; Manabu Musashi; Shuichi Ota; Takeshi Yoshida; Yuichi Shimizu; Makoto Chuma; Hiroshi Kawakami; Masahiro Asaka; Junji Tanaka; Masahiro Imamura; Masanobu Kobayashi; Hiroshi Itoh; Hironori Edamatsu; Leslie C. Sutherland; Rainer Brachmann

January 15, 2011

Small molecule inhibition of GDC-0449 refractory smoothened mutants and downstream mechanisms of drug resistance

Cancer Research, ISSN: 00085472 15387445

Gerrit J. P. Dijkgraaf; Bruno Alicke; Lasse Weinmann; Thomas Januario; Kristina West; Zora Modrusan; Burdick; Richard Goldsmith; Kirk D. Robarge; Daniel P. Sutherlin; Suzie J. Scales; Stephen Gould; Robert Yauch; Frederic J. De Sauvage

January 15, 2011

A hybrid approach to advancing quantitative prediction of tissue distribution of basic drugs in human

Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333

Patrick Poulin; Sean Ekins; Frank-Peter Theil

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