Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 4801 - 4850 OF 15176 RESULTS

June 1, 2016

A new triglycyl peptide linker for antibody-drug conjugates (ADCs) with improved targeted killing of cancer cells

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Rajeeva Singh; Yulius Y. Setiady; Jose Ponte; Yelena Kovtun; Katharine C. Lai; E. Erica Hong; Nathan Fishkin; Ling Dong; Gregory Jones; Jennifer A. Coccia; Leanne Lanieri; Karen Veale; Juliet A. Costoplus; Anna Skaletskaya; Rabih Gabriel; Paulin Salomon; Rui Wu; Qifeng Qiu; Hans Erickson; John M. Lambert; Ravi Chari; Wayne C. Widdison

June 1, 2016

In Vitro Skin Models and Their PredictabilProliferative Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Rats Lesions in Thyroid Follicular Cells of Dwarfs Derived from Wistar Hannover GALAS Ratsng Normal and Disease Biology, Pharmacology, and Toxicity

Toxicologic Pathology, ISSN: 15331601 01926233

Dimitry Danilenko; Gail L. Phillips; Dolores Diaz

June 1, 2016

Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: Prospective placebo-controlled clinical studies

EMBO Molecular Medicine, ISSN: 17574684 17574676

Jérémie Decalf; Kristin V. Tarbell; Armanda Casrouge; Jeffrey D. Price; Grace Linder; Estelle Mottez; Philippe Sultanik; Vincent Mallet; Stanislas Pol; Darragh Duffy; Matthew L. Albert

June 1, 2016

Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: A randomised, double-blind, placebo-controlled, phase 2 trial

The Lancet Respiratory Medicine, ISSN: 22132619 22132600

Jürgen Behr; Elisabeth Bendstrup; Bruno Crestani; Andreas Günther; Horst Olschewski; C Magnus Sköld; Athol Wells; Wim Wuyts; Dirk Koschel; Michael Kreuter; Benoît Wallaert; Chin-Yu Lin; Jürgen Beck; Carlo Albera

June 1, 2016

Pictilisib for oestrogen receptor-positive, aromatase inhibitor-resistant, advanced or metastatic breast cancer (FERGI): a randomised, double-blind, placebo-controlled, phase 2 trial

The Lancet Oncology, ISSN: 14745488 14702045

Ian E. Krop; Ingrid A. Mayer; Vinod Ganju; Maura N. Dickler; Stephen Johnston; Serafin Morales; Denise A. Yardley; Melichar; Andres Forero; Soo Chin Lee; Richard de Boer; Katarina Petrakova; Susanne Vallentin; Edith A. Perez; Martine Piccart; Matthew Ellis; Eric P. Winer; Steven Gendreau; Mika K. Derynck; Lackner; Gallia Levy; Jiaheng Qiu; Jing He; Schmid

June 1, 2016

An Overview of the Pathogenesis of Immune-mediated Skin Injury

Toxicologic Pathology, ISSN: 15331601 01926233

Dimitry Danilenko

June 1, 2016

Development of a Physiologically Based Pharmacokinetic Model for Itraconazole Pharmacokinetics and Drug–Drug Interaction Prediction

Clinical Pharmacokinetics, ISSN: 11791926 03125963

Yuan Chen; Fang Ma; Tong Lu; Nageshwar Budha; Jin Y. Jin; Jane R. Kenny; Harvey Wong; Cornelis E. Hop; Jialin Mao

June 1, 2016

Nonselective inhibition of the epigenetic transcriptional regulator BET induces marked lymphoid and hematopoietic toxicity in mice

Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X

Dong U. Lee; Paula Katavolos; Gopinath S. Palanisamy; Arna Katewa; Charly Sioson; Janice Corpuz; Jodie Pang; Kevin Dement; Edna F. Choo; Nico Ghilardi; Dolores Diaz; Dimitry Danilenko

June 1, 2016

Relationship between Baseline and Early Changes in C-Reactive Protein and Interleukin-6 Levels and Clinical Response to Tocilizumab in Rheumatoid Arthritis

Arthritis Care and Research, ISSN: 21514658 2151464X

Jianmei Wang; Jenny Devenport; Jason M. Low; Dale Yu; Hitraya

June 1, 2016

Examining Manufacturing Readiness for Breakthrough Drug Development

AAPS PharmSciTech, ISSN: 15309932

Earl S. Dye; Annie Sturgess; Gargi Maheshwari; Kimberly May; Colleen Ruegger; Usha Ramesh; Heow Tan; Keith Cockerill; John Groskoph; Emanuela Lacana; Sau L. Lee; Sarah Pope Miksinski

June 1, 2016

Investigation of Dose-Dependent Factors Limiting Oral Bioavailability: Case Study with the PI3K-δ Inhibitor

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Po-Chang Chiang; Daniel P. Sutherlin; Jodie Pang; Laurent Salphati

June 1, 2016

Prediction of drug-drug interactions arising from CYP3A induction using a physiologically based dynamic models

Drug Metabolism and Disposition, ISSN: 1521009X 00909556

Lisa M. Almond; Sophie Mukadam; Iain Gardner; Krystle Okialda; Susan C. Wong; Oliver Hatley; Suzanne Tay; Karen Rowland-Yeo; Masoud Jamei; Amin Rostami-Hodjegan; Jane R. Kenny

June 1, 2016

Molecular simulations of micellar aggregation of polysorbate 20 ester fractions and their interaction with N-phenyl-1-naphthylamine dye

Biophysical Chemistry, ISSN: 18734200 03014622

Mauro Lapelosa; Thomas W. Patapoff; Isidro E. Zarraga

June 1, 2016

Serum periostin is associated with type 2 immunity in severe asthma

Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749

Mats W. Johansson; Michael D. Evans; Gina M. Crisafi; Cécile T.J. Holweg; Matthews; Jarjour

June 1, 2016

Age-related macular degeneration: Complement in action

Immunobiology, ISSN: 18783279 01712985

Menno Van Lookeren Campagne; Erich C. Strauss; Brian L. Yaspan

June 1, 2016

Visual phenomena perceived during pars plana vitrectomy under peribulbar block and monitored anaesthesia care

British Journal of Ophthalmology, ISSN: 14682079 00071161

Hema L. Ramkumar; Azadeh Khatibi; William R. Freeman; Giulio Barteselli; Isaac C. Ezon; Payam Amini; Lucie Sharpsten; Cheryl A. Arcinue; Joseph T. Nezgoda; Henry A. Ferreyra; Michael H. Goldbaum

June 1, 2016

Visual and Anatomic Outcomes in Patients with Diabetic Macular Edema with Limited Initial Anatomic Response to Ranibizumab in RIDE and RISE Presented in part at: American Academy of Ophthalmology Annual Meeting, October 2014, Chicago, Illinois; And 38th Macula Society Annual Meeting, February 2015, Scottsdale, Arizona.

Ophthalmology, ISSN: 15494713 01616420

Dante Joseph Pieramici; Pin-Wen Wang; Beiying Ding; Shamika Gune

June 1, 2016

Tocilizumab in early progressive rheumatoid arthritis: FUNCTION, a randomised controlled trial

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Gerd R. Burmester; William F. Rigby; Ronald Van Vollenhoven; Jonathan Kay; Rubbert-Roth; Ariella Kelman; Sophie Dimonaco; Nina Mitchell

June 1, 2016

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type

Annals of the Rheumatic Diseases, ISSN: 14682060 00034967

Sebastian Unizony; Villarreal; Miloslavsky; Na Lu; Merkel; Spiera; Seo; Langford; Hoffman; Kallenberg; E. William St. Clair; Iklé; Tchao; Linna Ding; Paul Brunetta; Hyon Choi; Paul A. Monach; Fervenza; John H. Stone; Specks

June 1, 2016

Assessment of disease-related therapeutic protein drug-drug interaction for etrolizumab in patients with moderately to severely active ulcerative colitis

Journal of Clinical Pharmacology, ISSN: 15524604 00912700

Xiaohui Wei; Jane R. Kenny; Leslie Dickmann; Romeo MacIuca; Looney; Meina Tao Tang

June 1, 2016

Cost-Effectiveness Model for Chemoimmunotherapy Options in Patients with Previously Untreated Chronic Lymphocytic Leukemia Unsuitable for Full-Dose Fludarabine-Based Therapy

Value in Health, ISSN: 15244733 10983015

Ursula Becker; Andrew Briggs; Santiago G. Moreno; Joshua A. Ray; Phuong Ngo; Kunal Samanta

June 1, 2016

Cycling in the nucleus: Regulation of RNA 3' processing and nuclear organization of replication-dependent histone genes

Current Opinion in Cell Biology, ISSN: 18790410 09550674

Valentina Romeo; Daniel Schümperli

June 1, 2016

Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: A case study using aromatic amine mutagenicity

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Ernst Ahlberg; Alexander Amberg; Lisa Beilke; Dave Bower; Kevin P. Cross; Laura Custer; Kevin A. Ford; Jacky Van Gompel; James Harvey; Masamitsu Honma; Robert A. Jolly; Elisabeth Joossens; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Lara Kuhnke; Penny Leavitt; Russell Naven; Claire Neilan; Donald P. Quigley; Dana Shuey; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Angela White; Joerg Wichard; Craig Zwickl; Glenn J. Myatt

June 1, 2016

Principles and procedures for implementation of ICH M7 recommended (Q)SAR analyses

Regulatory Toxicology and Pharmacology, ISSN: 10960295 02732300

Alexander Amberg; Lisa Beilke; Joel P. Bercu; Dave Bower; Alessandro Brigo; Kevin P. Cross; Laura Custer; Krista Dobo; Eric Dowdy; Kevin A. Ford; Susanne Glowienke; Jacky Van Gompel; James Harvey; Catrin Hasselgren; Masamitsu Honma; Robert A. Jolly; Raymond Kemper; Michelle Kenyon; Naomi Kruhlak; Penny Leavitt; Scott Miller; Wolfgang Muster; John Nicolette; Andreja Plaper; Mark Powley; Donald P. Quigley; M. Vijayaraj Reddy; Hans-Peter Spirkl; Lidiya Stavitskaya; Andrew Teasdale; Sandy Weiner; Dennie S. Welch; Angela White; Joerg Wichard; Glenn J. Myatt

May 30, 2016

NLRP3 recruitment by NLRC4 during Salmonella infection

Journal of Experimental Medicine, ISSN: 15409538 00221007

Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva M. Dixit

May 19, 2016

Depletion of major pathogenic cells in asthma by targeting CRTh2

JCI insight, ISSN: 23793708

Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif

May 19, 2016

Depletion of major pathogenic cells in asthma by targeting CRTh2

JCI insight, ISSN: 23793708

Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif

May 19, 2016

Depletion of major pathogenic cells in asthma by targeting CRTh2

JCI insight,

Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif

May 18, 2016

An enzymatic deconjugation method for the analysis of small molecule active drugs on antibody-drug conjugates

mAbs, ISSN: 19420870 19420862

Yi Li; Christine Gu; Jason Gruenhagen; Peter M. Yehl; Nik P. Chetwyn; Colin D. Medley

May 18, 2016

Reproducible pharmacogenomic profiling of cancer cell line panels

Nature, ISSN: 14764687 00280836

Matthias Peter; Eva Lin; Jenille Tan; Yihong Yu; Billy Lam; Steve Lianoglou; Richard M. Neve; Scott E. Martin; Jeffrey Settleman; Robert Yauch; Richard Bourgon

May 12, 2016

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

ACS Medicinal Chemistry Letters, ISSN: 19485875

Alexander M. Taylor; Alexandre Côté; Michael C. Hewitt; Richard Pastor; Yves Leblanc; Christopher G. Nasveschuk; F. Anthony Romero; Terry Crawford; Nico Cantone; Hariharan Jayaram; Jeremy Setser; Jeremy Murray; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Andrew R. Conery; Richard T Cummings; Leslie A. Dakin; E. Megan Flynn; Oscar W Huang; Susan Kaufman; Patricia J. Keller; James R. Kiefer; Tommy Lai; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Henry Lu; Eneida Pardo; Vickie Tsui; Jian Wang; Yongyun Wang; Zhaowu Xu; Fen Yan; Dong Yu; Laura E. Zawadzke; Xiaoqin Zhu; Xiaoyu Zhu; Robert J. Sims; Andrea G Cochran; Steve Bellon; James E. Audia; Steven Magnuson; Brian K Albrecht

May 12, 2016

Mechanistic Insights into Radical-Mediated Oxidation of Tryptophan from ab Initio Quantum Chemistry Calculations and QM/MM Molecular Dynamics Simulations

Journal of Physical Chemistry A, ISSN: 15205215 10895639

Geoffrey P. F. Wood; Alavattam Sreedhara; Jamie M. R. Moore; John Wang; Bernhardt L. Trout

May 12, 2016

Fragment Molecular Orbital Method Applied to Lead Optimization of Novel Interleukin-2 Inducible T-Cell Kinase (ITK) Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Alexander Heifetz; Giancarlo Trani; Matteo Aldeghi; Colin H. Mackinnon; Paul A. McEwan; Frederick A. Brookfield; Ewa I. Chudyk; Mike Bodkin; Zhonghua Pei; Jason D. Burch; Daniel F. Ortwine

May 10, 2016

Randomized open-label phase II trial of apitolisib (GDC-0980), a novel inhibitor of the PI3K/mammalian target of rapamycin pathway, versus everolimus in patients with metastatic renal cell carcinoma

Journal of Clinical Oncology, ISSN: 15277755 0732183X

Thomas Powles; Lackner; Stephane Oudard; Bernard Escudier; Christy Ralph; Janet E. Brown; Robert E. Hawkins; Daniel Castellano; Brian I. Rini; Michael D. Staehler; Alain Ravaud; Wei Lin; Bridget O'Keeffe; Wang; Shan Lu; Jill M. Spoerke; Huw; Michelle Byrtek; Rui Zhu; Joseph A. Ware; Robert J. Motzer

May 10, 2016

Polarizing the Neuron through Sustained Co-expression of Alternatively Spliced Isoforms

Cell Reports, ISSN: 22111247

Karen Yap; Yixin Xiao; Brad A. Friedman; H. Shawn Je; Eugene V. Makeyev

May 7, 2016

Atezolizumab in patients with locally advanced and metastatic urothelial carcinoma who have progressed following treatment with platinum-based chemotherapy: A single-arm, multicentre, phase 2 trial

The Lancet, ISSN: 1474547X 01406736

Jonathan E. Rosenberg; Jean Hoffman-Censits; Thomas Powles; Michiel S Van Der Heijden; Arjun V. Balar; Andrea Necchi; Nancy Dawson; Peter H O'Donnell; Ani Balmanoukian; Yohann Loriot; Sandy Srinivas; Margitta M. Retz; Petros Grivas; Richard W. Joseph; Matthew D. Galsky; Mark T. Fleming; Petrylak; Jose Luis Perez-Gracia; Howard A. Burris; Daniel Castellano; Christina Canil; Joaquim Bellmunt; Dean Bajorin; Dorothee Nickles; Richard Bourgon; Garrett M Frampton; Na Cui; Sanjeev Mariathasan; Oyewale Abidoye; Gregg D. Fine; Robert Dreicer

May 5, 2016

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

Nature, ISSN: 14764687 00280836

Jianhua Li; Erick Lu; Tangsheng Yi; Jason G. Cyster

May 5, 2016

The extracellular interactome of the human adenovirus family reveals diverse strategies for immunomodulation

Nature Communications, ISSN: 20411723

Nadia Martinez-Martin; Sree R. Ramani; Jason A. Hackney; Irene Tom; Bernd Wranik; Michelle Chan; Johnny Wu; Maciej Paluch; Kentaro Takeda; Hass; Hilary F. Clark; Lino C. Gonzalez Jr.

May 3, 2016

The impact of persistence with therapy on inpatient admissions and emergency room visits in the US among patients with multiple sclerosis

Journal of Medical Economics, ISSN: 1941837X 13696998

Nina Parikh Thomas; Suellen Curkendall; Amanda M. Farr; Elaine B. Yu; Hurley

May 3, 2016

Mismatch repair deficiency testing in clinical practice

Expert Review of Molecular Diagnostics, ISSN: 17448352 14737159

Natalia Buza; James Ziai; Pei Hui

May 2, 2016

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22

Journal of Clinical Investigation, ISSN: 15588238 00219738

Marianne R. Spalinger; Stephanie Kasper; Claudia Gottier; Silvia Lang; Kirstin Atrott; Stephan R. Vavricka; Sylvie Scharl; Petrus M. Gutte; Markus G. Grütter; Hans-Dietmar Beer; Emmanuel Contassot; Andrew A. Chan; Xuezhi Dai; David J. Rawlings; Florian Mair; Burkhard Becher; Werner Falk; Fried; Gerhard Rogler; Michael Scharl

May 1, 2016

Roles of periostin in respiratory disorders

American Journal of Respiratory and Critical Care Medicine, ISSN: 15354970 1073449X

Kenji Izuhara; Simon J. Conway; Bethany B. Moore; Hisako Matsumoto; Cécile T.J. Holweg; Matthews; Joseph R. Arron

May 1, 2016

Clearance of extractables and leachables from single-use technologies via ultrafiltration/diafiltration operations

Biotechnology Progress, ISSN: 15206033

Nicholas Magarian; Kate Lee; Kunal Nagpal; Ken Skidmore; Ekta Mahajan

May 1, 2016

Exploring concordance of Patient-Reported information on patientsLikeMe and medical claims data at the patient level

Journal of Medical Internet Research, ISSN: 14388871

Gabriel S. Eichler; Elisenda Cochin; Jian Han; Hu; Timothy E. Vaughan; Paul Wicks; Charles E. Barr; Jenny Devenport

May 1, 2016

Expression profile of BCL-2, BCL-XL, and MCL-1 predicts pharmacological response to the BCL-2 selective antagonist venetoclax in multiple myeloma models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Elizabeth A. Punnoose; Joel D. Leverson; Franklin V. Peale Jr.; Erwin R. Boghaert; Lisa D. Belmont; Nguyen Tan; Amy Young; Michael J. Mitten; Ellen Ingalla; Darbonne; Anatol Oleksijew; Paul Tapang; Peng Yue; Jason Oeh; Leslie Lee; Maïga; Wayne J. Fairbrother; Amiot; Andrew J. Souers; Deepak Sampath

May 1, 2016

Prediction and quantification of splice events from RNA-seq data

PLoS ONE, ISSN: 19326203

Leonard D. Goldstein; Yi Cao; Gregoire Pau; Michael Lawrence; Thomas D Wu; Somasekar Seshagiri; Robert Gentleman

May 1, 2016

Perspective on a Modified Developmental and Reproductive Toxicity Testing Strategy for Cancer Immunotherapy

International Journal of Toxicology, ISSN: 1092874X 10915818

Prell; Wendy Halpern; Gautham K. Rao

May 1, 2016

Targeting Cell Death Pathways for Therapeutic Intervention in Kidney Diseases

Seminars in Nephrology, ISSN: 15584488 02709295

Garg; Domagoj Vucic

May 1, 2016

Patterns of early and delayed visual response to ranibizumab treatment for neovascular age-related macular degeneration

JAMA Ophthalmology, ISSN: 21686165

Glenn Stoller; Gregg T. Kokame; Richard F. Dreyer; Howard Shapiro; Lisa Tuomi

May 1, 2016

Delay in initiation of adjuvant trastuzumab therapy leads to decreased overall survival and relapse-free survival in patients with HER2-positive non-metastatic breast cancer

Breast Cancer Research and Treatment, ISSN: 15737217 01676806

Christopher Gallagher; Kenneth More; Tripthi V. Kamath; Anthony Masaquel; Annie Guérin; Raluca Ionescu-Ittu; Marjolaine Gauthier-Loiselle; Roy Nitulescu; Nicholas Sicignano; Elizabeth Butts; Eric Q. Wu; Brian Barnett

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