Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 801 - 850 OF 15197 RESULTS

Pharmacokinetics, Pharmacodynamics, and Safety of Etrolizumab in Children With Moderately to Severely Active Ulcerative Colitis or Crohn's Disease: Results from a Phase 1 Randomized Trial
Inflammatory Bowel Diseases, ISSN: 15364844
Wenhui Zhang; Astrid Scalori; Franklin Fuh; Jacqueline McBride; Gaohong She; Jaroslaw Kierkus; Bartosz Korczowksi; Regan Li; Mariam Abouhossein; Alysha Kadva; Park; Meina Tao Tang
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Using a peptide-based mass spectrometry approach to quantitate proteolysis of an intact heterogeneous procollagen substrate by BMP1 for antagonistic antibody screening
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
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New and Emerging Research on Solute Carrier and ATP Binding Cassette Transporters in Drug Discovery and Development: Outlook From the International Transporter Consortium
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Kathleen M. Giacomini; Sook Wah Yee; Megan L. Koleske; Ling Zou; Pär Matsson; Eugene C. Chen; Deanna L. Kroetz; Miles A. Miller; Elnaz Gozalpour; Xiaoyan Chu
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology,
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Mechanisms underlying DMARD inefficacy in difficult-to-treat rheumatoid arthritis: a narrative review with systematic literature search
Rheumatology, ISSN: 14620332
Nadia M T Roodenrijs; Paco M J Welsing; Joël van Roon; Jan L M Schoneveld; Marlies C. van der Goes; György Nagy; Michael J. Townsend; Jacob M. Van Laar
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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Enduring undetectable MRD and updated outcomes in relapsed/refractory CLL after fixed-duration venetoclax-rituximab
Blood, ISSN: 15280020 00064971
John F. Seymour; Thomas J. Kipps; Barbara Eichhorst; D'Rozario; Carolyn J. Owen; Sarit E. Assouline; Nicole Lamanna; Tadeusz Robak; Javier De La Serna; Jaeger; Guillaume Cartron; Marco Montillo; Clemens H. Mellink; Brenda Chyla; Anesh Panchal; Tong Lu; Jenny Q. Wu; Yanwen Jiang; Marcus Lefebure; Michelle Boyer; Kater
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GNE-064: A Potent, Selective, and Orally Bioavailable Chemical Probe for the Bromodomains of SMARCA2 and SMARCA4 and the Fifth Bromodomain of PBRM1
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Alexander M. Taylor; Christopher Bailey; Lisa D. Belmont; Robert Campbell; Nico Cantone; Alexandre Côté; Terry Crawford; Richard T Cummings; Kevin Dement; Martin Duplessis; Megan Flynn; Andrew C. Good; Hon-Ren Huang; Shivangi Joshi; Yves Leblanc; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Florence Poy; F. Anthony Romero; Peter Sandy; Yong Tang; Vickie Tsui; Laura E. Zawadzke; Robert J. Sims; James E. Audia; Steve Bellon; Steven Magnuson; Brian K Albrecht; Andrea G Cochran
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Determination of BET Specific Surface Area of Hydrate-Anhydrate Systems Susceptible to Phase Transformation Using Inverse Gas Chromatography
AAPS PharmSciTech,
Minhthi Bui; Karthik Nagapudi; Paroma Chakravarty
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports, ISSN: 22111247
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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Disease-associated oligodendrocyte responses across neurodegenerative diseases
Cell Reports,
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife, ISSN: 2050084X
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Development of Dual Practical Manufacturing Routes to Cognate Pyrrolobenzodiazepine-Based Linker-Drugs
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
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Importance of Green and Sustainable Chemistry in the Chemical Industry
Organic Process Research and Development, ISSN: 1520586X 10836160
Juan Colberg; King Kuok Hii; Stefan G. Koenig
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EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation
eLife,
Ariel Pribluda; Anneleen Daemen; Anthony Lima; Xi Wang; Marc Hafner; Chungkee Poon; Zora Modrusan; Anand K. Katakam; Oded Foreman; Jeffrey Eastham; Jeffrey Hung; Benjamin Haley; Julia T. Garcia; Erica L. Jackson; Melissa Junttila
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Single-cell analysis reveals clonally expanded tumor-associated CD57 +CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Michael Fehlings; Leesun Kim; Xiangnan Guan; Kobe Yuen; Alireza Tafazzol; Shomyseh Sanjabi; Oliver A. Zill; Deepali Rishipathak; Andrew Wallace; Alessandra Nardin; Siming Ma; Ana Milojkovic; Evan W. Newell; Sanjeev Mariathasan; Mahesh Yadav
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Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics
Journal of the American Chemical Society, ISSN: 15205126 00027863
Carmela Molinaro; Yukie Kawasaki; George Wanyoike; Taiki Nishioka; Tsuyoshi Yamamoto; Snedecor; Sarah J. Robinson; Francis Gosselin
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Analytical techniques for characterizing diastereomers of phosphorothioated oligonucleotides
Journal of Chromatography A, ISSN: 18733778 00219673
Tao Chen; Shijia Tang; Yige Fu; José G. Napolitano; Kelly Zhang
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The impact of low adsorption surfaces for the analysis of DNA and RNA oligonucleotides
Journal of Chromatography A, ISSN: 00219673
Honorine Lardeux; Alexandre Goyon; Kelly Zhang; Jennifer M Nguyen; Matthew A Lauber; Davy Guillarme; Valentina D'Atri
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 18733778 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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Liquid chromatography coupled with photodiode array and a multivariate curve resolution – Alternating least square algorithm for identification and quantification of co-eluting impurities in pharmaceutical analysis
Journal of Chromatography A, ISSN: 00219673
Davide Vecchietti; Akira Nishio; Yuichiro Fujita; Takeshi Yoshida; Toshinobu Yanagisawa; Dawen Kou
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 15573265 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Monitoring multiple quality attributes of a complex Fc-fusion protein during cell culture production processes by mD-LC-MS peptide mapping
Talanta, ISSN: 00399140
Julien Camperi; Sanket Dahotre; Davy Guillarme; Cinzia Stella
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First-In-Human Phase I Study of the OX40 Agonist MOXR0916 in Patients with Advanced Solid Tumors
Clinical Cancer Research, ISSN: 10780432
Tae Won Kim; Howard A. Burris; Maria J. de Miguel Luken; Pishvaian; Bang; Michael S. Gordon; Ahmad Awada; D. Ross Camidge; F. Stephen Hodi; Grant A. McArthur; Miller; Andrés Cervantes; Laura Q.M. Chow; Alexander M. Lesokhin; Annemie Rutten; Mario Sznol; Deepali Rishipathak; Shang-Chiung Chen; Stefanich; Tony Pourmohamad; Maria Anderson; Jeong Kim; Mahrukh Huseni; Ina Rhee; Siu
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Attached Nitrogen Test by 13C-14N Solid-State NMR Spectroscopy for the Structure Determination of Heterocyclic Isomers
Organic Letters, ISSN: 15237052 15237060
Rick W. Dorn; Brendan J. Wall; Sarah B. Ference; Sean R. Norris; Joseph W. Lubach; Aaron J. Rossini; Brett VanVeller
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Immune microenvironment characteristics in multiple myeloma progression from transcriptome profiling
Frontiers in Oncology, ISSN: 2234943X
Jin Wang; Yi Hu; Habib Hamidi; Cedric Dos Santos; Jingyu Zhang; Elizabeth A. Punnoose; Wenjin Li
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The “η-sweet-spot” (ηmax) in liquid-assisted mechanochemistry: polymorph control and the role of a liquid additive as either a catalyst or an inhibitor in resonant acoustic mixing (RAM)
Faraday Discussions, ISSN: 13645498 13596640
Lori Gonnet; Tristan H. Borchers; Cameron B. Lennox; Jogirdas Vainauskas; Yong Teoh; Hatem M. Titi; Christopher J. Barrett; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friščić
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mRNA Display and Its Growing Potential in the Discovery of de Novo Therapeutic Peptide Candidates
ACS Symposium Series, ISSN: 19475918 00976156
Christina Helmling; Christian N. Cunningham
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mRNA Display and Its Growing Potential in the Discovery of de Novo Therapeutic Peptide Candidates
ACS Symposium Series, ISSN: 00976156
Christina Helmling; Christian N. Cunningham
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Preface
ACS Symposium Series, ISSN: 19475918 00976156
Swapnil V. Ghodge; Kaustav Biswas; Andrei A. Golosov
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NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability
ACS Symposium Series, ISSN: 00976156
Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother
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NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability
ACS Symposium Series, ISSN: 19475918 00976156
Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother
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Chiral Amines via Enantioselective π-Allyliridium-C,O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration
Accounts of Chemical Research,
Craig E. Stivala; Jason R. Zbieg; Peng Liu; Michael J. Krische
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VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors - Efficacy, Safety, and Biomarker Results
Clinical Cancer Research,
Geoffrey J. Lindeman; Tharu M. Fernando; Rebecca Bowen; Katarzyna J. Jerzak; Xinni Song; Thomas Decker; Frances Boyle; Steven McCune; Anne Armstrong; Catherine Shannon; Gianfilippo Bertelli; Ching-Wei Chang; Rupal Desai; Kushagra Gupta; Wilson; Aulde Flechais; Aditya Bardia
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Chiral Amines via Enantioselective π-Allyliridium-C,O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration
Accounts of Chemical Research, ISSN: 15204898
Craig E. Stivala; Jason R. Zbieg; Peng Liu; Michael J. Krische
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Chiral Amines via Enantioselective π-Allyliridium- C, O-Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration
Accounts of Chemical Research, ISSN: 15204898 00014842
Craig E. Stivala; Jason R. Zbieg; Peng Liu; Michael J. Krische
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Untreated bleeds in people with hemophilia A in a noninterventional study and intrapatient comparison after initiating emicizumab in HAVEN 1–3
Research and Practice in Thrombosis and Haemostasis, ISSN: 24750379
Michael U. Callaghan; Elina Asikanius; Michaela Lehle; Johannes Oldenburg; Johnny N. Mahlangu; Marianne Uguen; Sammy Chebon; Kruse-Jarres; Jiménez-Yuste; Midori Shima; Peter C. Trask; Kempton; Craig Kessler; Gallia Levy; Flora Peyvandi
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VERONICA: Randomized Phase II Study of Fulvestrant and Venetoclax in ER-Positive Metastatic Breast Cancer Post-CDK4/6 Inhibitors - Efficacy, Safety, and Biomarker Results
Clinical Cancer Research, ISSN: 15573265 10780432
Geoffrey J. Lindeman; Tharu M. Fernando; Rebecca Bowen; Katarzyna J. Jerzak; Xinni Song; Thomas Decker; Frances Boyle; Steven McCune; Anne Armstrong; Catherine Shannon; Gianfilippo Bertelli; Ching-Wei Chang; Rupal Desai; Kushagra Gupta; Wilson; Aulde Flechais; Aditya Bardia
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Pharmacokinetics and Exposure-Response Analysis of Venetoclax + Obinutuzumab in Chronic Lymphocytic Leukemia: Phase 1b Study and Phase 3 CLL14 Trial
Advances in Therapy, ISSN: 18658652 0741238X
Divya Samineni; Leonid Gibiansky; Wang; Shweta Vadhavkar; Richa Rajwanshi; Tandon; Arijit Sinha; Othman Al-Sawaf; Kirsten Fischer; Michael Hallek; Ahmed Hamed Salem; Chunze Li; Dale Miles
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Omalizumab treatment reduces asthma exacerbations regardless of airway bronchodilator reversibility
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
Samuel DeLeon; Franco Barsanti; Cécile T.J. Holweg; Bongin Yoo; Blaine Creasy; Michael E. Wechsler
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Pharmacokinetics and Exposure-Response Analysis of Venetoclax + Obinutuzumab in Chronic Lymphocytic Leukemia: Phase 1b Study and Phase 3 CLL14 Trial
Advances in Therapy, ISSN: 18658652 0741238X
Divya Samineni; Leonid Gibiansky; Bei Wang; Shweta Vadhavkar; Richa Rajwanshi; Tandon; Arijit Sinha; Othman Al-Sawaf; Kirsten Fischer; Michael Hallek; Ahmed Hamed Salem; Chunze Li; Dale Miles
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Erratum to Gene Set Enrichment Analyses Identify Pathways Involved in Genetic Risk for Diabetic Retinopathy. Am J Ophthalmol 2022;233:111-123 (American Journal of Ophthalmology (2022) 233 (111–123), (S0002939421003366), (10.1016/j.ajo.2021.06.014))
American Journal of Ophthalmology, ISSN: 18791891 00029394
Lucia Sobrin; Gayatri Susarla; Lynn K. Stanwyck; John M. Rouhana; Ashley Li; Samuela Pollack; Robert P. Igo; Richard A. Jensen; Xiaohui Li; Maggie C.Y. Ng; Albert V Smith; Jane Z. Kuo; Kent D. Taylor; Barry I. Freedman; Donald W. Bowden; Alan Penman; Ching J. Chen; Jamie E. Craig; Sharon G. Adler; Emily Y. Chew; Mary Frances Cotch; Brian L. Yaspan; Paul Mitchell; Jie Jin Wang; Barbara E.K. Klein; Tien Y. Wong; Jerome I. Rotter; Kathryn Burdon; Sudha K. Iyengar; Ayellet V. Segrè
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Applications of Model-Based Meta-Analysis in Drug Development
Pharmaceutical Research, ISSN: 1573904X 07248741
Phyllis Chan; Kirill Peskov; Xuyang Song
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Comment on A Implication of baseline levels and early changes of C-reactive protein for subsequent clinical outcomes of patients with rheumatoid arthritis treated with tocilizumab'
Annals of the Rheumatic Diseases, ISSN: 14682060 00034967
Attila Pethoe-Schramm; Jenny Devenport; William Reiss
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Application of Empirical Scalars to Enable Early Prediction of Human Hepatic Clearance Using in Vitro-In Vivo Extrapolation in Drug Discovery: An Evaluation of 173 Drugs
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Robert Jones; Christian Leung; Jae H. Chang; Suzanne Brown; Ning Liu; Zhengyin Yan; Jane R. Kenny; Broccatelli
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Safety and efficacy of mosunetuzumab, a bispecific antibody, in patients with relapsed or refractory follicular lymphoma: a single-arm, multicentre, phase 2 study
The Lancet Oncology, ISSN: 14702045
Lihua E. Budde; Laurie H. Sehn; Matthew Matasar; Stephen J. Schuster; Sarit E. Assouline; Pratyush Giri; Kuruvilla; Miguel Canales; Sascha Dietrich; Keith Fay; Matthew Ku; Loretta J. Nastoupil; Chan Yoon Cheah; Michael C. Wei; Shen Yin; Chi-Chung Li; Huang Huang; Antonia Kwan; Elicia M. Penuel; Nancy L. Bartlett
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Untreated bleeds in people with hemophilia A in a noninterventional study and intrapatient comparison after initiating emicizumab in HAVEN 1–3
Research and Practice in Thrombosis and Haemostasis,
Michael U. Callaghan; Elina Asikanius; Michaela Lehle; Johannes Oldenburg; Johnny N. Mahlangu; Marianne Uguen; Sammy Chebon; Kruse-Jarres; Jiménez-Yuste; Midori Shima; Peter C. Trask; Kempton; Craig Kessler; Gallia Levy; Flora Peyvandi
View on Scopus
A Phase II Study of Ziv-Aflibercept in Patients With Advanced Extrapancreatic Neuroendocrine Tumors
Pancreas, ISSN: 15364828 08853177
Kimberly Perez; Matthew H. Kulke; Nora K. Horick; Eileen Regan; Christopher Graham; Samantha Scheutz; Danielle Stonely; Peter C. Enzinger; Charles Fuchs; Jill N. Allen; Andrea C. Enzinger; Jeffrey W. Clark; Jennifer A. Chan
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Single-cell analysis reveals clonally expanded tumor-associated CD57+ CD8 T cells are enriched in the periphery of patients with metastatic urothelial cancer responding to PD-L1 blockade
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Michael Fehlings; Leesun Kim; Xiangnan Guan; Kobe Yuen; Alireza Tafazzol; Shomyseh Sanjabi; Oliver A. Zill; Deepali Rishipathak; Andrew Wallace; Alessandra Nardin; Siming Ma; Ana Milojkovic; Evan W. Newell; Sanjeev Mariathasan; Mahesh Yadav
View on Scopus
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